相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。A Prospective Randomized Controlled Study of Long-Term Combination Therapy Using Ursodeoxycholic Acid and Bezafibrate in Patients With Primary Biliary Cirrhosis and Dyslipidemia
Kenichi Hosonuma et al.
AMERICAN JOURNAL OF GASTROENTEROLOGY (2015)
Animal Models of Primary Biliary Cirrhosis
Tomohiro Katsumi et al.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2015)
Unmet Challenges in Immune-Mediated Hepatobiliary Diseases
Ulrich Beuers et al.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2015)
Efficacy of Obeticholic Acid in Patients With Primary Biliary Cirrhosis and Inadequate Response to Ursodeoxycholic Acid
Gideon M. Hirschfield et al.
GASTROENTEROLOGY (2015)
Fibrates and cholestasis
Nisanne S. Ghonem et al.
HEPATOLOGY (2015)
Systems biologic analysis of T regulatory cells genetic pathways in murine primary biliary cirrhosis
Yin-Hu Wang et al.
JOURNAL OF AUTOIMMUNITY (2015)
Unmet clinical need in autoimmune liver diseases
Jessica K. Dyson et al.
JOURNAL OF HEPATOLOGY (2015)
New paradigms in the treatment of hepatic cholestasis: From UDCA to FXR, PXR and beyond
Ulrich Beuers et al.
JOURNAL OF HEPATOLOGY (2015)
Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial
Brent A. Neuschwander-Tetri et al.
LANCET (2015)
Fenofibrate is effective adjunctive therapy in the treatment of primary biliary cirrhosis: A meta-analysis
Alla Y. Grigorian et al.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY (2015)
Genetics in PBC: What Do the Risk Genes Teach Us?
Gideon M. Hirschfield et al.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2015)
Genetics in PSC: What Do the Risk Genes Teach Us?
Trine Folseraas et al.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2015)
Women and Primary Biliary Cirrhosis
Ying Sun et al.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2015)
Gene Replacement Therapy for Genetic Hepatocellular Jaundice
Remco van Dijk et al.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2015)
New Therapies for Primary Biliary Cirrhosis
Annarosa Floreani et al.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2015)
Prevention of Spontaneous Hepatocarcinogenesis in Farnesoid X Receptor-Null Mice by Intestinal-Specific Farnesoid X Receptor Reactivation
Chiara Degirolamo et al.
HEPATOLOGY (2015)
Good Maternal and Fetal Outcomes for Pregnant Women With Primary Biliary Cirrhosis
Palak J. Trivedi et al.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2014)
Levels of Alkaline Phosphatase and Bilirubin Are Surrogate End Points of Outcomes of Patients With Primary Biliary Cirrhosis: An International Follow-up Study
Willem J. Lammers et al.
GASTROENTEROLOGY (2014)
The Bile Acid Receptor TGR5 Activates the TRPA1 Channel to Induce Itch in Mice
TinaMarie Lieu et al.
GASTROENTEROLOGY (2014)
Ongoing Activation of Autoantigen-Specific B Cells in Primary Biliary Cirrhosis
Jun Zhang et al.
HEPATOLOGY (2014)
Peroxisome Proliferator-Activated Receptor α Activates Human Multidrug Resistance Transporter 3/ATP-Binding Cassette Protein Subfamily B4 Transcription and Increases Rat Biliary Phosphatidylcholine Secretion
Nisanne S. Ghonem et al.
HEPATOLOGY (2014)
IL-12/Th1 and IL-23/Th17 Biliary Microenvironment in Primary Biliary Cirrhosis: Implications for Therapy
Chen-Yen Yang et al.
HEPATOLOGY (2014)
Obeticholic Acid, a Farnesoid X Receptor Agonist, Improves Portal Hypertension by Two Distinct Pathways in Cirrhotic Rats
Len Verbeke et al.
HEPATOLOGY (2014)
Genomic Portrait of Resectable Hepatocellular Carcinomas: Implications of RB1 and FGF19 Aberrations for Patient Stratification
Sung-Min Ahn et al.
HEPATOLOGY (2014)
Pruritus in Cholestasis: Facts and Fiction
Ulrich Beuers et al.
HEPATOLOGY (2014)
Distinct from its canonical effects, deletion of IL-12p40 induces cholangitis and fibrosis in interleukin-2Rα-/- mice
Yuan Yao et al.
JOURNAL OF AUTOIMMUNITY (2014)
Murine autoimmune cholangitis requires two hits: Cytotoxic KLRG1+ CD8 effector cells and defective T regulatory cells
Wenting Huang et al.
JOURNAL OF AUTOIMMUNITY (2014)
Optimising risk stratification in primary biliary cirrhosis: AST/platelet ratio index predicts outcome independent of ursodeoxycholic acid response
Palak J. Trivedi et al.
JOURNAL OF HEPATOLOGY (2014)
THE FIRST PRIMARY BILIARY CIRRHOSIS (PBC) PHASE 3 TRIAL IN TWO DECADES - AN INTERNATIONAL STUDY OF THE FXR AGONIST OBETICHOLIC ACID IN PBC PATIENTS
F. Nevens et al.
JOURNAL OF HEPATOLOGY (2014)
Bezafibrate normalizes alkaline phosphatase in primary biliary cirrhosis patients with incomplete response to ursodeoxycholic acid
Sabela Lens et al.
LIVER INTERNATIONAL (2014)
New therapeutics in primary biliary cirrhosis: will there ever be light?
Pietro Invernizzi et al.
LIVER INTERNATIONAL (2014)
Bile acid receptors as targets for drug development
Frank G. Schaap et al.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2014)
Mechanisms of tissue injury in autoimmune liver diseases
Evaggelia Liaskou et al.
SEMINARS IN IMMUNOPATHOLOGY (2014)
Old and Novel Therapies for Primary Biliary Cirrhosis
Albert Pares
SEMINARS IN LIVER DISEASE (2014)
The Immunobiology and Pathophysiology of Primary Biliary Cirrhosis
Gideon M. Hirschfield et al.
Annual Review of Pathology-Mechanisms of Disease (2013)
Pleiotropic Roles of Bile Acids in Metabolism
Thomas Q. de Aguiar Vallim et al.
CELL METABOLISM (2013)
Anti-CD40 ligand monoclonal antibody delays the progression of murine autoimmune cholangitis
H. Tanaka et al.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2013)
Sex and Age Are Determinants of the Clinical Phenotype of Primary Biliary Cirrhosis and Response to Ursodeoxycholic Acid
Marco Carbone et al.
GASTROENTEROLOGY (2013)
Identification of fibroblast growth factor 15 as a novel mediator of liver regeneration and its application in the prevention of post-resection liver failure in mice
Iker Uriarte et al.
GUT (2013)
α5β1-integrins are sensors for tauroursodeoxycholic acid in hepatocytes
Holger Gohlke et al.
HEPATOLOGY (2013)
Therapeutic Effect of Cytotoxic T Lymphocyte Antigen 4/Immunoglobulin on a Murine Model of Primary Biliary Cirrhosis
Amy Dhirapong et al.
HEPATOLOGY (2013)
Antimitochondrial antibody heterogeneity and the xenobiotic etiology of primary biliary cirrhosis
Richy C. Y. Chen et al.
HEPATOLOGY (2013)
Impact of Primary Biliary Cirrhosis on Perceived Quality of Life: The UK-PBC National Study
George F. Mells et al.
HEPATOLOGY (2013)
The role of natural killer cells in autoimmune liver disease: A comprehensive review
Kelly Hudspeth et al.
JOURNAL OF AUTOIMMUNITY (2013)
Y chromosome loss in male patients with primary biliary cirrhosis
Ana Lleo et al.
JOURNAL OF AUTOIMMUNITY (2013)
The TGR5 receptor mediates bile acid-induced itch and analgesia
Farzad Alemi et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
A validated clinical tool for the prediction of varices in PBC: The Newcastle Varices in PBC Score
Imran Patanwala et al.
JOURNAL OF HEPATOLOGY (2013)
Treatment of autoimmune liver disease: current and future therapeutic options
Palak J. Trivedi et al.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE (2013)
Selective Activation of Nuclear Bile Acid Receptor FXR in the Intestine Protects Mice Against Cholestasis
Salvatore Modica et al.
GASTROENTEROLOGY (2012)
A biliary HCO3- umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes
Simon Hohenester et al.
HEPATOLOGY (2012)
Noninvasive elastography-based assessment of liver fibrosis progression and prognosis in primary biliary cirrhosis
Christophe Corpechot et al.
HEPATOLOGY (2012)
Epidemiology of primary sclerosing cholangitis and primary biliary cirrhosis: A systematic review
Kirsten Boonstra et al.
JOURNAL OF HEPATOLOGY (2012)
Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease
Geoffrey Porez et al.
JOURNAL OF LIPID RESEARCH (2012)
Synthetic Farnesoid X Receptor Agonists Induce High-Density Lipoprotein-Mediated Transhepatic Cholesterol Efflux in Mice and Monkeys and Prevent Atherosclerosis in Cholesteryl Ester Transfer Protein Transgenic Low-Density Lipoprotein Receptor (-/-) Mice
Eva Hambruch et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2012)
Diagnosis of primary biliary cirrhosis
Gideon M. Hirschfield
BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY (2011)
Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease
Raffaella M. Gadaleta et al.
GUT (2011)
Dual Farnesoid X Receptor/TGR5 Agonist INT-767 Reduces Liver Injury in the Mdr2-/- (Abcb4-/-) Mouse Cholangiopathy Model by Promoting Biliary HCO3- Output
Anna Baghdasaryan et al.
HEPATOLOGY (2011)
AN INTERNATIONAL STUDY EVALUATING THE FARNESOID X RECEPTOR AGONIST OBETICHOLIC ACID AS MONOTHERAPY IN PBC
K. V. Kowdley et al.
JOURNAL OF HEPATOLOGY (2011)
Early primary biliary cirrhosis: Biochemical response to treatment and prediction of long-term outcome
Christophe Corpechot et al.
JOURNAL OF HEPATOLOGY (2011)
FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis
Serkan Kir et al.
SCIENCE (2011)
Baseline Ductopenia and Treatment Response Predict Long-Term Histological Progression in Primary Biliary Cirrhosis
Teru Kumagi et al.
AMERICAN JOURNAL OF GASTROENTEROLOGY (2010)
The membrane-bound bile acid receptor TGR5 (Gpbar-1) is localized in the primary cilium of cholangiocytes
Verena Keitel et al.
BIOLOGICAL CHEMISTRY (2010)
Pathogenesis of Cholestatic Liver Disease and Therapeutic Approaches
Gideon M. Hirschfield et al.
GASTROENTEROLOGY (2010)
Pharmacotherapy of cholestatic liver diseases
Gustav Paumgartner
JOURNAL OF DIGESTIVE DISEASES (2010)
The independent effects of fatigue and UDCA therapy on mortality in primary biliary cirrhosis: Results of a 9 year follow-up
David E. Jones et al.
JOURNAL OF HEPATOLOGY (2010)
Sustained upregulation of sodium taurocholate cotransporting polypeptide and bile salt export pump and downregulation of cholesterol 7α-hydroxylase in the liver of patients with end-stage primary biliary cirrhosis
Yasuaki Takeyama et al.
MEDICAL MOLECULAR MORPHOLOGY (2010)
Inhibition of Endothelin-1-Mediated Contraction of Hepatic Stellate Cells by FXR Ligand
Jiang Li et al.
PLOS ONE (2010)
Separating mitogenic and metabolic activities of fibroblast growth factor 19 (FGF19)
Xinle Wu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Farnesoid X Receptor Critically Determines the Fibrotic Response in Mice but Is Expressed to a Low Extent in Human Hepatic Stellate Cells and Periductal Myofibroblasts
Peter Fickert et al.
AMERICAN JOURNAL OF PATHOLOGY (2009)
Antiatherosclerotic effect of farnesoid X receptor
Andrea Mencarelli et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2009)
Improved Prognosis of Patients With Primary Biliary Cirrhosis That Have a Biochemical Response to Ursodeoxycholic Acid
Edith M. M. Kuiper et al.
GASTROENTEROLOGY (2009)
Primary Biliary Cirrhosis
Keith D. Lindor et al.
HEPATOLOGY (2009)
EASL Clinical Practice Guidelines: Management of cholestatic liver diseases
Ulrich Beuers et al.
JOURNAL OF HEPATOLOGY (2009)
The Bile Acid Sensor Farnesoid X Receptor Is a Modulator of Liver Immunity in a Rodent Model of Acute Hepatitis
Andrea Mencarelli et al.
JOURNAL OF IMMUNOLOGY (2009)
Portal Hypertension and Primary Biliary Cirrhosis: Effect of Long-Term Ursodeoxycholic Acid Treatment
Pierre-Michel Huet et al.
GASTROENTEROLOGY (2008)
Biochemical response to ursodeoxycholic acid and long-term prognosis in primary biliary cirrhosis
Christophe Corpechot et al.
HEPATOLOGY (2008)
Farnesoid X Receptor Antagonizes Nuclear Factor κB in Hepatic Inflammatory Response
Yan-Dong Wang et al.
HEPATOLOGY (2008)
Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine
Insook Kim et al.
JOURNAL OF LIPID RESEARCH (2007)
Primary biliary cirrhosis, hyperlipidemia, and atherosclerotic risk: A systematic review
Alexey Sorokin et al.
ATHEROSCLEROSIS (2007)
Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice
Insook Kim et al.
CARCINOGENESIS (2007)
Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor
Fan Yang et al.
CANCER RESEARCH (2007)
Excellent long-term survival in patients with primary biliary cirrhosis and biochemical response to ursodeoxycholic acid
A Parés et al.
GASTROENTEROLOGY (2006)
Drug insight: mechanisms and sites of action of ursodeoxycholic acid in cholestasis
Ulrich Beuers
NATURE CLINICAL PRACTICE GASTROENTEROLOGY & HEPATOLOGY (2006)
Upregulation of a basolateral FXR-dependent bile acid efflux transporter OST alpha-OST beta in cholestasis in humans and rodents
James L. Boyer et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2006)
OSTα-OSTβ:: A major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia
N Ballatori et al.
HEPATOLOGY (2005)
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
T Inagaki et al.
CELL METABOLISM (2005)
α-Crystallin is a target gene of the farnesoid X-activated receptor in human livers
FY Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
A farnesoid X receptor-small heterodimer partner regulatory cascade modulates tissue metalloproteinase inhibitor-1 and matrix metalloprotease expression in hepatic stellate cells and promotes resolution of liver fibrosis
S Fiorucci et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
The effect of ursodeoxycholic acid therapy on the natural course of primary biliary cirrhosis
C Corpechot et al.
GASTROENTEROLOGY (2005)
The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis
S Fiorucci et al.
GASTROENTEROLOGY (2004)
Farnesoid X receptor activates transcription of the phospholipid pump MDR3
L Huang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Enterohepatic circulation of bile salts in farnesoid x receptor-deficient mice - Efficient intestinal bile salt absorption in the absence of ileal bile acid-binding protein
T Kok et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Survival and symptom progression in a geographically based cohort of patients with primary biliary cirrhosis: Follow-up for up to 28 years
M Prince et al.
GASTROENTEROLOGY (2002)
6α-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity
R Pellicciari et al.
JOURNAL OF MEDICINAL CHEMISTRY (2002)
A mouse model of hepatocellular carcinoma - Ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice
K Nicholes et al.
AMERICAN JOURNAL OF PATHOLOGY (2002)
Primary biliary cirrhosis: Incidence and predictive factors of cirrhosis development in ursodiol-treated patients
C Corpechot et al.
GASTROENTEROLOGY (2002)
Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor
M Ananthanarayanan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
The therapeutic effects of ursodeoxycholic acid as an anti-apoptotic agent
CMP Rodrigues et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2001)
Hepatobiliary transporter expression in percutaneous liver biopsies of patients with cholestatic liver diseases
G Zollner et al.
HEPATOLOGY (2001)
Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
CJ Sinal et al.
CELL (2000)
A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis
B Goodwin et al.
MOLECULAR CELL (2000)