期刊
EVOLUTION EQUATIONS AND CONTROL THEORY
卷 4, 期 2, 页码 221-232出版社
AMER INST MATHEMATICAL SCIENCES-AIMS
DOI: 10.3934/eect.2015.4.221
关键词
Bilinear systems; bounded controls; Pontryagin principle; cancer chemotherapy
The aim of this paper is to study the optimal control problem for finite dimensional bilinear systems with bounded controls. We characterize an optimal control that minimizes a quadratic cost functional using Pontryagin's minimum principle, we derive sufficient conditions of uniqueness from the fixed point theorem, and we develop an algorithm that allows to compute the optimal control and the associated states. Our approach is applied to a cancer treatment by chemotherapy in order to determine the optimal dose of a killing agent.
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