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AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2013)
Adaptive β-cell proliferation increases early in high-fat feeding in mice, concurrent with metabolic changes, with induction of islet cyclin D2 expression
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AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2013)
被撤回的出版物: Betatrophin: A Hormone that Controls Pancreatic β Cell Proliferation (Retracted article. See vol. 168, pg. 326, 2017)
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DIABETES (2013)
Cytoplasmic-Nuclear Trafficking of G1/S Cell Cycle Molecules and Adult Human 13-Cell Replication A Revised Model of Human β-Cell G1/S Control
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DIABETES (2013)
beta-Cell Mass and Turnover in Humans Effects of obesity and aging
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DIABETES CARE (2013)
Adaptive changes of human islets to an obesogenic environment in the mouse
S. Gargani et al.
DIABETOLOGIA (2013)
Regulation of mTORC1 and its impact on gene expression at a glance
Mathieu Laplante et al.
JOURNAL OF CELL SCIENCE (2013)
Nutrient Sensing, Metabolism, and Cell Growth Control
Hai-Xin Yuan et al.
MOLECULAR CELL (2013)
Topologically Heterogeneous Beta Cell Adaptation in Response to High-Fat Diet in Mice
Johanne H. Ellenbroek et al.
PLOS ONE (2013)
Regional Differences in Islet Distribution in the Human Pancreas - Preferential Beta-Cell Loss in the Head Region in Patients with Type 2 Diabetes
Xiaojun Wang et al.
PLOS ONE (2013)
Novel Insulin Sensitizer Modulates Nutrient Sensing Pathways and Maintains β-Cell Phenotype in Human Islets
Nidhi Rohatgi et al.
PLOS ONE (2013)
A Novel Strategy to Increase the Proliferative Potential of Adult Human β-Cells While Maintaining Their Differentiated Phenotype
Haytham Aly et al.
PLOS ONE (2013)
Liver-Derived Systemic Factors Drive β Cell Hyperplasia in Insulin-Resistant States
Abdelfattah El Ouaamari et al.
CELL REPORTS (2013)
Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure
Chutima Talchai et al.
CELL (2012)
Loss of HGF/c-Met Signaling in Pancreatic β-Cells Leads to Incomplete Maternal β-Cell Adaptation and Gestational Diabetes Mellitus
Cem Demirci et al.
DIABETES (2012)
ChREBP Mediates Glucose-Stimulated Pancreatic β-Cell Proliferation
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DIABETES (2012)
Free Fatty Acids Block Glucose-Induced β-Cell Proliferation in Mice by Inducing Cell Cycle Inhibitors p16 and p18
Jordan Pascoe et al.
DIABETES (2012)
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Rohit N. Kulkarni et al.
DIABETES (2012)
A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets
P. Marchetti et al.
DIABETOLOGIA (2012)
Hepatocyte Growth Factor Plays a Key Role in Insulin Resistance-Associated Compensatory Mechanisms
Tiago G. Araujo et al.
ENDOCRINOLOGY (2012)
Deletion of GαZ Protein Protects against Diet-induced Glucose Intolerance via Expansion of β-Cell Mass
Michelle E. Kimple et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Formation of a Human β-Cell Population within Pancreatic Islets Is Set Early in Life
Brigid E. Gregg et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2012)
MicroRNAs contribute to compensatory β cell expansion during pregnancy and obesity
Cecile Jacovetti et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
Andrew P. Morris et al.
NATURE GENETICS (2012)
In Vitro Proliferation of Adult Human Beta-Cells
Sabine Rutti et al.
PLOS ONE (2012)
The CaMK4/CREB/IRS-2 Cascade Stimulates Proliferation and Inhibits Apoptosis of β-Cells
Bo Liu et al.
PLOS ONE (2012)
β-cell metabolic alterations under chronic nutrient overload in rat and human islets
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ISLETS (2012)
Differential Development of Glucose Intolerance and Pancreatic Islet Adaptation in Multiple Diet Induced Obesity Models
Bilal Omar et al.
NUTRIENTS (2012)
Early peroxisome proliferator-activated receptor gamma regulated genes involved in expansion of pancreatic beta cell mass
Yurena Vivas et al.
BMC MEDICAL GENOMICS (2011)
Control of Pancreatic β Cell Regeneration by Glucose Metabolism
Shay Porat et al.
CELL METABOLISM (2011)
Disruption of Hepatocyte Growth Factor/c-Met Signaling Enhances Pancreatic β-Cell Death and Accelerates the Onset of Diabetes
Jose Mellado-Gil et al.
DIABETES (2011)
Glucose stimulates human beta cell replication in vivo in islets transplanted into NOD-severe combined immunodeficiency (SCID) mice
H. E. Levitt et al.
DIABETOLOGIA (2011)
Calcium/calmodulin-dependent kinase IV controls glucose-induced Irs2 expression in mouse beta cells via activation of cAMP response element-binding protein
S. J. Persaud et al.
DIABETOLOGIA (2011)
Nicotinamide mononucleotide protects against pro-inflammatory cytokine-mediated impairment of mouse islet function
P. W. Caton et al.
DIABETOLOGIA (2011)
Glucose Regulates Cyclin D2 Expression in Quiescent and Replicating Pancreatic β-Cells Through Glycolysis and Calcium Channels
Seth J. Salpeter et al.
ENDOCRINOLOGY (2011)
Processing of proglucagon to GLP-1 in pancreatic α-cells: is this a paracrine mechanism enabling GLP-1 to act on β-cells?
N. M. Whalley et al.
JOURNAL OF ENDOCRINOLOGY (2011)
Hepatocyte growth factor twenty years on: Much more than a growth factor
Takahiro Nakamura et al.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2011)
Postnatal Development of Numbers and Mean Sizes of Pancreatic Islets and Beta-Cells in Healthy Mice and GIPRdn Transgenic Diabetic Mice
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PLOS ONE (2011)
Altered Insulin Receptor Signalling and β-Cell Cycle Dynamics in Type 2 Diabetes Mellitus
Franco Folli et al.
PLOS ONE (2011)
Glucose Intolerance and Reduced Proliferation of Pancreatic β-Cells in Transgenic Pigs With Impaired Glucose-Dependent Insulinotropic Polypeptide Function
Simone Renner et al.
DIABETES (2010)
β-Cell Failure in Diet-Induced Obese Mice Stratified According to Body Weight Gain: Secretory Dysfunction and Altered Islet Lipid Metabolism Without Steatosis or Reduced β-Cell Mass
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DIABETES (2010)
Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy
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DIABETOLOGIA (2010)
Conditional ablation of Gsk-3β in islet beta cells results in expanded mass and resistance to fat feeding-induced diabetes in mice
Y. Liu et al.
DIABETOLOGIA (2010)
Rgs16 and Rgs8 in embryonic endocrine pancreas and mouse models of diabetes
Alethia Villasenor et al.
DISEASE MODELS & MECHANISMS (2010)
β-Cell Mass Dynamics and Islet Cell Plasticity in Human Type 2 Diabetes
Stephen C. Hanley et al.
ENDOCRINOLOGY (2010)
Secretion and Dipeptidyl Peptidase-4-Mediated Metabolism of Incretin Hormones after a Mixed Meal or Glucose Ingestion in Obese Compared to Lean, Nondiabetic Men
Richard D. Carr et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2010)
Significant Human β-Cell Turnover Is Limited to the First Three Decades of Life as Determined by in Vivo Thymidine Analog Incorporation and Radiocarbon Dating
S. Perl et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2010)
FoxM1 Is Up-Regulated by Obesity and Stimulates β-Cell Proliferation
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MOLECULAR ENDOCRINOLOGY (2010)
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
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NATURE GENETICS (2010)
Increased β-cell volume in mice fed a high-fat diet A dynamic study over 12 months
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ISLETS (2010)
Glycogen Synthase Kinase-3 and Mammalian Target of Rapamycin Pathways Contribute to DNA Synthesis, Cell Cycle Progression, and Proliferation in Human Islets
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DIABETES (2009)
Glucose Effects on Beta-Cell Growth and Survival Require Activation of Insulin Receptors and Insulin Receptor Substrate 2
Anke Assmann et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet
Chie Ebato et al.
CELL METABOLISM (2008)
Exendin-4 stimulation of cyclin A2 in beta-cell proliferation
Woo-Jin Song et al.
DIABETES (2008)
β-Cell replication is the primary mechanism subserving the postnatal expansion of β-cell mass in humans
Juris J. Meier et al.
DIABETES (2008)
GLP-1 receptor signaling:: effects on pancreatic β-cell proliferation and survival
J. Buteau
DIABETES & METABOLISM (2008)
Crucial role of insulin receptor substrate-2 in compensatory β-cell hyperplasia in response to high fat diet-induced insulin resistance
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DIABETES OBESITY & METABOLISM (2008)
Pancreatic β-cell mass in European subjects with type 2 diabetes
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DIABETES OBESITY & METABOLISM (2008)
A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility
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GENOME RESEARCH (2008)
Separate impact of obesity and glucose tolerance on the incretin effect in normal subjects and type 2 diabetic patients
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DIABETES (2008)
Proliferation of sorted human and rat beta cells
G. Parnaud et al.
DIABETOLOGIA (2008)
Glucose infusion in mice -: A new model to induce β-cell replication
Laura C. Alonso et al.
DIABETES (2007)
PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism
Gema Medina-Gomez et al.
PLOS GENETICS (2007)
Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance
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JOURNAL OF CLINICAL INVESTIGATION (2007)
Adipose tissue production of hepatocyte growth factor contributes to elevated serum HGF in obesity
Lauren N. Bell et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2006)
Transcription factor Fox01 mediates glucagon-like peptide-1 effects on pancreatic β-cell mass
J Buteau et al.
DIABETES (2006)
Relationship between β-cell mass and fasting blood glucose concentration in humans
RA Ritzel et al.
DIABETES CARE (2006)
Stimulation of pancreatic β-cell replication by incretins involves transcriptional induction of cyclin D1 via multiple signalling pathways
BN Friedrichsen et al.
JOURNAL OF ENDOCRINOLOGY (2006)
Very slow turnover of β-cells in aged adult mice
M Teta et al.
DIABETES (2005)
Dietary-fat-induced obesity in mice results in beta cell hyperplasia but not increased insulin release: evidence for specificity of impaired beta cell adaptation
R Hull et al.
DIABETOLOGIA (2005)
Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice
T Uchida et al.
NATURE MEDICINE (2005)
Targeted elimination of peroxisome proliferator-activated receptor γ in β cells leads to abnormalities in islet mass without compromising glucose homeostasis
ED Rosen et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Increased islet volume but unchanged islet number in ob/ob mice
T Bock et al.
DIABETES (2003)
beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
AE Butler et al.
DIABETES (2003)
Hepatocyte growth factor stimulates proliferation of pancreatic β-cells particularly in the presence of subphysiological glucose concentrations
S Gahr et al.
JOURNAL OF MOLECULAR ENDOCRINOLOGY (2002)
Islet β cell expression of constitutively active Akt1/PKBα induces striking hypertrophy, hyperplasia, and hyperinsulinemia
E Bernal-Mizrachi et al.
JOURNAL OF CLINICAL INVESTIGATION (2001)
Regulation of pancreatic β-cell growth and survival by the serine/threonine protein kinase Akt1/PKBα
RL Tuttle et al.
NATURE MEDICINE (2001)
The role of postprandial releases of insulin and incretin hormones in meal-induced satiety - effect of obesity and weight reduction
C Verdich et al.
INTERNATIONAL JOURNAL OF OBESITY (2001)
Adaptation of β-cell mass to substrate oversupply:: enhanced function with normal gene expression
GM Steil et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2001)
Stimulated endocrine cell proliferation and differentiation in transplanted human pancreatic islets -: Effects of the ob gene and compensatory growth of the implantation organ
B Tyrberg et al.
DIABETES (2001)
Glucose sensing in pancreatic beta-cells - A model for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus
FC Schuit et al.
DIABETES (2001)
Genetic obesity unmasks nonlinear interactions between murine type 2 diabetes susceptibility loci
JP Stoehr et al.
DIABETES (2000)
Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory β-cell hyperplasia
N Kubota et al.
DIABETES (2000)
Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia
A Garcia-Ocaña et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
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