期刊
ADVANCES IN NUTRITION
卷 4, 期 6, 页码 711-717出版社
OXFORD UNIV PRESS
DOI: 10.3945/an.113.004770
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资金
- NICHD NIH HHS [F32 HD071715-01, T32 HD007466-17] Funding Source: Medline
- NIDDK NIH HHS [T32 DK007754-14] Funding Source: Medline
Parenteral nutrition is a life-saving therapy for infants with intestinal failure. However, long-term parenteral nutrition carries the risk of progressive liver disease. Substantial data has implicated components of parenteral soybean oil in the pathogenesis of parenteral nutrition-associated liver disease (PNALD). Elevated serum concentrations of phytosterols, an abundance of omega-6 polyunsaturated fatty acids, and a relative paucity of a-tocopherol have been associated with the risk of cholestasis and hepatic injury observed in PNALD. Currently available treatment strategies include the reduction of the dose of administered parenteral soybean oil and/or the replacement of parenteral soybean oil with alternative parenteral lipid emulsions. The purpose of this review is to provide an overview of the pathogenetic mechanisms associated with the development of PNALD and the data evaluating currently available treatment strategies.
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