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Abrogation of De novo Lipogenesis by Stearoyl-CoA Desaturase 1 Inhibition Interferes with Oncogenic Signaling and Blocks Prostate Cancer Progression in Mice
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Reduced levels of SCD1 accentuate palmitate-induced stress in insulin-producing β-cells
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Despite Antiatherogenic Metabolic Characteristics, SCD1-Deficient Mice Have Increased Inflammation and Atherosclerosis
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ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2009)
Relationships between serum fatty acid composition and multiple markers of inflammation and endothelial function in an elderly population
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ATHEROSCLEROSIS (2009)
Stearoyl-CoA desaturase-1 deficiency attenuates obesity and insulin resistance in leptin-resistant obese mice
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Absence of stearoyl-CoA desaturase-1 does not promote DSS-induced acute colitis
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Endothelial dysfunction and diabetes: roles of hyperglycemia, impaired insulin signaling and obesity
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CELL AND TISSUE RESEARCH (2009)
Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome
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CURRENT OPINION IN LIPIDOLOGY (2009)
Individual Stearoyl-CoA Desaturase 1 Expression Modulates Endoplasmic Reticulum Stress and Inflammation in Human Myotubes and Is Associated With Skeletal Muscle Lipid Storage and Insulin Sensitivity In Vivo
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Tissue Inhibitor of Metalloproteinase 3 Deficiency Causes Hepatic Steatosis and Adipose Tissue Inflammation in Mice
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Skin-specific Deletion of Stearoyl-CoA Desaturase-1 Alters Skin Lipid Composition and Protects Mice from High Fat Diet-induced Obesity
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JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Stearoyl-CoA desaturase 1 deficiency protects mice from immune-mediated liver injury
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LABORATORY INVESTIGATION (2009)
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NATURE MEDICINE (2009)
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Susceptibility of Pancreatic Beta Cells to Fatty Acids Is Regulated by LXR/PPARα-Dependent Stearoyl-Coenzyme A Desaturase
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PLOS ONE (2009)
Inhibition of StearoylCoA Desaturase-1 Inactivates Acetyl-CoA Carboxylase and Impairs Proliferation in Cancer Cells: Role of AMPK
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PLOS ONE (2009)
Induction of stearoyl-CoA desaturase protects human arterial endothelial cells against lipotoxicity
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AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2008)
Metabolomics reveals that hepatic stearoyl-CoA desaturase 1 downregulation exacerbates inflammation and acute colitis
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CELL METABOLISM (2008)
Inhibition of stearoyl-coenzyme A desaturase 1 dissociates insulin resistance and obesity from atherosclerosis
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Liver gene expression analysis reveals endoplasmic reticulum stress and metabolic dysfunction in SCD1-deficient mice fed a very low-fat diet
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Serum fatty acid composition and indices of stearyl-CoA desaturase activity are associated with systemic inflammation:: longitudinal analyses inn middle-aged men
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BRITISH JOURNAL OF NUTRITION (2008)
Absence of stearoyl-CoA desaturase-1 ameliorates features of the metabolic syndrome in LDLR-deficient mice
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JOURNAL OF LIPID RESEARCH (2008)
Insulin resistance and endothelial cell dysfunction: studies in mammalian models
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EXPERIMENTAL PHYSIOLOGY (2008)
Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis
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CELL METABOLISM (2007)
A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via toll-like receptors 2 and 4 and JNK-dependent pathways
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Chronic intermittent hypoxia induces atherosclerosis
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Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid-induced insulin resistance
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Laminar shear stress up-regulates the expression of stearoyl-CoA desaturase-1 in vascular endothelial cells
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CARDIOVASCULAR RESEARCH (2007)
Identification of ras-related nuclear protein, targeting protein for Xenopus kinesin-like protein 2, and stearoyl-CoA desaturase 1 as promising cancer targets from an RNAi-based screen.
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CANCER RESEARCH (2007)
Loss of stearoyl-CoA desaturase-1 improves insulin sensitivity in lean mice but worsens diabetes in leptin-deficient obese mice
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DIABETES (2007)
Stearoyl CoA desaturase 1 is elevated in obesity but protects against fatty acid-induced skeletal muscle insulin resistance in vitro
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DIABETOLOGIA (2006)
TLR4 links innate immunity and fatty acid-induced insulin resistance
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Mice fed a lipogenic methionine-choline-deficient diet develop hypermetabolism coincident with hepatic suppression of SCD-1
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Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans
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CELL METABOLISM (2005)
Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic β-cells from lipoapoptosis
AK Busch et al.
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Intermittent hypoxia induces hyperlipidemia in lean mice
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CIRCULATION RESEARCH (2005)
A Toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria
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Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates
J Wang et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Loss of stearoyl-CoA desaturase expression is a frequent event in prostate carcinoma
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INTERNATIONAL JOURNAL OF CANCER (2005)
Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1
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Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing β-oxidation in skeletal muscle
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High stearoyl-CoA desaturase protein and activity levels in simian virus 40 transformed-human lung fibroblasts
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Stearoyl-CoA desaturase 1 deficiency increases insulin signaling and glycogen accumulation in brown adipose tissue
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Free fatty acids promote hepatic lipotoxicity by stimulating TNF-α expression via a lysosomal pathway
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Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanisms
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Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscle
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Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors
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JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
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H Tsutsui et al.
CURRENT MOLECULAR MEDICINE (2003)
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CURRENT OPINION IN LIPIDOLOGY (2003)
β-Amyloid-specific upregulation of stearoyl coenzyme A desaturase-1 in macrophages
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic β-cell turnover and function
K Maedler et al.
DIABETES (2003)
Role of stearoyl-coenzyme A desaturase in lipid metabolism
M Miyazaki et al.
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS (2003)
Molecular targets of 1,25(OH)(2)D-3 in HC11 normal mouse mammary cell line
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JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2003)
Dietary cholesterol opposes PUFA-mediated repression of the stearoyl-CoA desaturase-1 gene by SREBP-1 independent mechanism
HJ Kim et al.
JOURNAL OF LIPID RESEARCH (2002)
Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets -: Evidence that β-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated
R Lupi et al.
DIABETES (2002)
Oleoyl-CoA is the major de novo product of stearoyl-CoA desaturase 1 gene isoform and substrate for the biosynthesis of the Harderian gland 1-alkyl-2,3-diacylglycerol
M Miyazaki et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Targeted disruption of stearoyl-CoA desaturase1 gene in mice causes atrophy of sebaceous and meibomian glands and depletion of wax esters in the eyelid
M Miyazaki et al.
JOURNAL OF NUTRITION (2001)
Scd3 -: A novel gene of the stearoyl-CoA desaturase family with restricted expression in skin
Y Zheng et al.
GENOMICS (2001)
The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1
M Miyazaki et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
The trans-10,cis-12 isomer of conjugated linoleic acid downregulates stearoyl-CoA desaturase 1 gene expression in 3T3-L1 adipocytes
YJ Choi et al.
JOURNAL OF NUTRITION (2000)
The N terminus of microsomal Δ9 stearoyl-CoA desaturase contains the sequence determinant for its rapid degradation
H Mziaut et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
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