期刊
ADVANCED HEALTHCARE MATERIALS
卷 3, 期 5, 页码 628-641出版社
WILEY
DOI: 10.1002/adhm.201300620
关键词
extracellular matrix; cardiovascular; tissue engineering; cell fate; stem cells
资金
- National Heart, Lung and Blood Institute of the US National Institutes of Health [R00HL098688]
- National Science Foundation [1249008]
- Department of Defense [W81XWH-12-C-0111]
- Stanford Cardiovascular Institute
- Directorate For Engineering [1249008] Funding Source: National Science Foundation
- Div Of Industrial Innovation & Partnersh [1249008] Funding Source: National Science Foundation
It is generally agreed that engineered cardiovascular tissues require cellular interactions with the local milieu. Within the microenvironment, the extracellular matrix (ECM) is an important support structure that provides dynamic signaling cues in part through its chemical, physical, and mechanical properties. In response to ECM factors, cells activate biochemical and mechanotransduction pathways that modulate their survival, growth, migration, differentiation, and function. This Review describes the role of ECM chemical composition, spatial patterning, and mechanical stimulation in the specification of cardiovascular lineages, with a focus on stem cell differentiation, direct transdifferentiation, and endothelial-to-mesenchymal transition. The translational application of ECMs is discussed in the context of cardiovascular tissue engineering and regenerative medicine.
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