期刊
ADVANCED HEALTHCARE MATERIALS
卷 3, 期 10, 页码 1629-1637出版社
WILEY-BLACKWELL
DOI: 10.1002/adhm.201400103
关键词
gold nanorods; layer-by-layer assembly; siRNA; photothermal therapy
资金
- Department of Defense [W81XWH-09-1-0212, W81XWH-12-1-0414]
- National Institute of Health [U54CA143837, U54CA151668]
- CPRIT from the state of Texas [RP121071]
- Ernest Cockrell Jr. Distinguished Endowed Chair
- National Natural Science Foundation of China [21231007, 21172274, 21121061]
- Program for Innovative Research Team in University of China [IRT1298]
- Key Project of Chinese Ministry of Education [313058]
- National Basic Research Program of China (973 Program) [2014CB845604]
- Fundamental Research Funds for the Central Universities
Cancer is a complex disease that usually requires several treatment modalities. A multifunctional nanotherapeutic system is designed, incorporating small interfering RNA (siRNA) and gold nanorods (Au NRs) for photothermal therapy. Surface-engineered Au NRs with polyethylenimine are synthesized using a layer-by-layer assembly and siRNA is absorbed on the surface. The siRNA is efficiently delivered into breast cancer cells, resulting in subsequent gene silencing. Cells are then irradiated with near-infrared (NIR) light, causing heat-induced anticancer activity. The combination of gene silencing and photothermal therapy results in effective inhibition of cell proliferation.
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