期刊
ACS SYNTHETIC BIOLOGY
卷 3, 期 5, 页码 273-279出版社
AMER CHEMICAL SOC
DOI: 10.1021/sb4000838
关键词
inducible gene expression; transcriptional amplification; magnetite nanoparticles; heat shock protein promoter; tetracycline-responsive transactivator
资金
- Ministry of Education, Culture, Sports, Science, and Technology (MEXT), Japan [24119512]
- Grants-in-Aid for Scientific Research [26119714, 24119512] Funding Source: KAKEN
By combining synthetic biology with nanotechnology, we demonstrate remote controlled gene expression using a magnetic field. Magnetite nanoparticles, which generate heat under an alternating magnetic field, have been developed to label cells. Magnetite nanoparticles and heat-induced therapeutic genes were introduced into tumor xenografts. The magnetically triggered gene expression resulted in tumor growth inhibition. This system shows great potential for controlling target gene expression in a space and time selective manner and may be used for remote control of cell functions via gene expression.
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