期刊
ACS SYNTHETIC BIOLOGY
卷 2, 期 5, 页码 216-222出版社
AMER CHEMICAL SOC
DOI: 10.1021/sb300075t
关键词
synthetic biology; design automation; liquid-handling robotics; laboratory automation; high-level programming language
资金
- Office of Science, Office of Biological and Environmental Research, of the U.S. Department of Energy [DE-AC02-05CH11231]
- Department of Energy, ARPA-E Electrofuels Program [DE-0000206-1577]
- National Science Foundation Graduate Research Fellowship Program [DGE 1106400]
- Berkeley Laboratory Directed Research and Development Program
Labor-intensive multistep biological tasks, such as the construction and cloning of DNA molecules, are prime candidates for laboratory automation. Flexible and biology-friendly operation of robotic equipment is key to its successful integration in biological laboratories, and the efforts required to operate a robot must be much smaller than the alternative manual lab work. To achieve these goals, a simple high-level biology-friendly robot programming language is needed. We have developed and experimentally validated such a language: Programming a Robot (PaR-PaR). The syntax and compiler for the language are based on computer science principles and a deep understanding of biological workflows. PaR-PaR allows researchers to use liquid-handling robots effectively, enabling experiments that would not have been considered previously. After minimal training, a biologist can independently write complicated protocols for a robot within an hour. Adoption of PaR-PaR as a standard cross-platform language would enable hand-written or software-generated robotic protocols to be shared across laboratories.
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