Nitrogen-Centered Nucleophile Catalyzed Thiol-Vinylsulfone Addition, Another Thiol-ene Click Reaction

A new group of nitrogen-centered nucleophilic catalysts for the thiol-Michael addition. click reactions is: examined. These nucleophiles showed efficient catalytic activities: as compared with traditional base catalysts, such as triethylamine, and are demonstrated to be a viable strategy for cross-linking polymerization reactions. Additionally, an experimental and computational mechanistic study was performed, suggesting a pathway for the nitrogen-centered catalyst to undergo the nucleophilic addition mechanism.