4.5 Review

The role of host autophagy machinery in controlling Toxoplasma infection

期刊

VIRULENCE
卷 10, 期 1, 页码 438-447

出版社

TAYLOR & FRANCIS INC
DOI: 10.1080/21505594.2018.1518102

关键词

Toxoplasma gondii; toxoplasmosis; autophagy; non-canonical autophagy; LC3-associated phagocytosis (LAP)

资金

  1. Institut National de la Sante et de la Recherche Medicale (Inserm)
  2. Fondation pour la Recherche Medicale [Equipe EQ20170336725]
  3. Labex Parafrap [ANR-11-LABX-0024]

向作者/读者索取更多资源

Toxoplasma gondii is an obligate intracellular parasitic protist that infects a wide range of warm-blooded vertebrates. Although this parasite can cause serious complications, infections are often asymptomatic, allowing T. gondii to persist in its host and possibly enhancing the chances of its transmission. T. gondii has thus evolved multiple mechanisms of host manipulation to establish chronic infection. This persistence involves a balance between host immunity and parasite evasion of this immune response. This review highlights recent investigations that have demonstrated the important role played by the autophagy machinery in this balance, both in parasite control by the host, and in host exploitation by the parasite.

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