相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Recombinant Human Activated Protein C as a Therapy for Severe Sepsis: Lessons Learned?
Steven M. Opal et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2013)
Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis The ACCESS Randomized Trial
Steven M. Opal et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2013)
Increased proportion of CD4+CD25+Foxp3+ regulatory T cells during early-stage sepsis in ICU patients
Feng-Ying Leng et al.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION (2013)
Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach
Richard S. Hotchkiss et al.
LANCET INFECTIOUS DISEASES (2013)
Genomic responses in mouse models poorly mimic human inflammatory diseases
Junhee Seok et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
A Historical Perspective on Sepsis
Peter A. Ward et al.
AMERICAN JOURNAL OF PATHOLOGY (2012)
Regulatory T Cells: Mechanisms of Differentiation and Function
Steven Z. Josefowicz et al.
ANNUAL REVIEW OF IMMUNOLOGY, VOL 30 (2012)
Effects of Recombinant Human Interleukin 7 on T-Cell Recovery and Thymic Output in HIV-Infected Patients Receiving Antiretroviral Therapy: Results of a Phase I/IIa Randomized, Placebo-Controlled, Multicenter Study
Y. Levy et al.
CLINICAL INFECTIOUS DISEASES (2012)
The immune response to severe bacterial infections: consequences for therapy
Evangelos J. Giamarellos-Bourboulis et al.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY (2012)
IL-7 Restores Lymphocyte Functions in Septic Patients
Fabienne Venet et al.
JOURNAL OF IMMUNOLOGY (2012)
Interleukin-7 Ameliorates Immune Dysfunction and Improves Survival in a 2-Hit Model of Fungal Sepsis
Jacqueline Unsinger et al.
JOURNAL OF INFECTIOUS DISEASES (2012)
BTLA expression contributes to septic morbidity and mortality by inducing innate inflammatory cell dysfunction
Nicholas J. Shubin et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2012)
Sepsis studies need new direction
Jonathan Cohen et al.
LANCET INFECTIOUS DISEASES (2012)
Safety and Activity of Anti-PD-L1 Antibody in Patients with Advanced Cancer
Julie R. Brahmer et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
Safety, Activity, and Immune Correlates of Anti-PD-1 Antibody in Cancer
Suzanne L. Topalian et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
IL-7 in human health and disease
Wangko Lundstroem et al.
SEMINARS IN IMMUNOLOGY (2012)
Interleukin-7 and immune reconstitution in cancer patients: a new paradigm for dramatically increasing overall survival
Michel Morre et al.
TARGETED ONCOLOGY (2012)
Interleukin-15 biology and its therapeutic implications in cancer
Jason C. Steel et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2012)
A prospective analysis of lymphocyte phenotype and function over the course of acute sepsis
Jonathan S. Boomer et al.
CRITICAL CARE (2012)
Peroxisome Proliferator-activated Receptor γ-induced T Cell Apoptosis Reduces Survival during Polymicrobial Sepsis
Martina Victoria Schmidt et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2011)
Mechanism of T cell exhaustion in a chronic environment
Hyun-Tak Jin et al.
BMB REPORTS (2011)
Prospects for TIM3-Targeted Antitumor Immunotherapy
Shin Foong Ngiow et al.
CANCER RESEARCH (2011)
Anti-TIM3 Antibody Promotes T Cell IFN-γ-Mediated Antitumor Immunity and Suppresses Established Tumors
Shin Foong Ngiow et al.
CANCER RESEARCH (2011)
Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases
Andreas Strasser et al.
EMBO JOURNAL (2011)
The CD4-like molecule LAG-3, biology and therapeutic applications
Sophie Sierro et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2011)
Immunomodulatory therapy for sepsis: an update
Eirini Christaki et al.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY (2011)
Immunoparalysis and nosocomial infection in children with multiple organ dysfunction syndrome
Mark W. Hall et al.
INTENSIVE CARE MEDICINE (2011)
Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure
Jonathan S. Boomer et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2011)
The Search for Effective Therapy for Sepsis Back to the Drawing Board?
Derek C. Angus
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2011)
An early circulating factor in severe sepsis modulates apoptosis of monocytes and lymphocytes
Ilia Vaki et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2011)
ICU-acquired immunosuppression and the risk for secondary fungal infections
Guillaume Monneret et al.
MEDICAL MYCOLOGY (2011)
Immunologic Alterations and the Pathogenesis of Organ Failure in the ICU
Steven M. Opal
SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE (2011)
Binding of Superantigen Toxins into the CD28 Homodimer Interface Is Essential for Induction of Cytokine Genes That Mediate Lethal Shock
Gila Arad et al.
PLOS BIOLOGY (2011)
Clinical review: flow cytometry perspectives in the ICU - from diagnosis of infection to monitoring of injury-induced immune dysfunctions
Fabienne Venet et al.
CRITICAL CARE (2011)
The late phase of sepsis is characterized by an increased microbiological burden and death rate
Gordon P. Otto et al.
CRITICAL CARE (2011)
Programmed death-1 levels correlate with increased mortality, nosocomial infection and immune dysfunctions in septic shock patients
Caroline Guignant et al.
CRITICAL CARE (2011)
Cytomegalovirus reactivation and associated outcome of critically ill patients with severe sepsis
Alexandra Heininger et al.
CRITICAL CARE (2011)
Granulocyte-colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) for sepsis: a meta-analysis
Lulong Bo et al.
CRITICAL CARE (2011)
Th17 and Regulatory T Cells in Mediating and Restraining Inflammation
Dan R. Littman et al.
CELL (2010)
Phase I Study of Recombinant Human Interleukin-7 Administration in Subjects with Refractory Malignancy
Claude Sportes et al.
CLINICAL CANCER RESEARCH (2010)
T-cell exhaustion: characteristics, causes and conversion
John S. Yi et al.
IMMUNOLOGY (2010)
Interleukin-7 (IL-7) Treatment Accelerates Neutrophil Recruitment through γδ T-Cell IL-17 Production in a Murine Model of Sepsis
Kevin R. Kasten et al.
INFECTION AND IMMUNITY (2010)
IL-15 Prevents Apoptosis, Reverses Innate and Adaptive Immune Dysfunction, and Improves Survival in Sepsis
Shigeaki Inoue et al.
JOURNAL OF IMMUNOLOGY (2010)
Sepsis-Induced Apoptosis Leads to Active Suppression of Delayed-Type Hypersensitivity by CD8+ Regulatory T Cells through a TRAIL-Dependent Mechanism
Jacqueline Unsinger et al.
JOURNAL OF IMMUNOLOGY (2010)
IL-7 Promotes T Cell Viability, Trafficking, and Functionality and Improves Survival in Sepsis
Jacqueline Unsinger et al.
JOURNAL OF IMMUNOLOGY (2010)
Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis
Pavan Brahmamdam et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2010)
Immunotherapy for Sepsis - A New Approach against an Ancient Foe
Richard S. Hotchkiss et al.
NEW ENGLAND JOURNAL OF MEDICINE (2010)
Treatment with granulocyte-macrophage colony-stimulating factor is associated with reduced indoleamine 2,3-dioxygenase activity and kynurenine pathway catabolites in patients with severe sepsis and septic shock
Joerg C. Schefold et al.
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES (2010)
T-CELL ACTIVATION DIFFERENTIALLY MEDIATES THE HOST RESPONSE TO SEPSIS
Kevin R. Kasten et al.
SHOCK (2010)
An Enigmatic Tail of CD28 Signaling
Jonathan S. Boomer et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)
PD-L1 blockade improves survival in experimental sepsis by inhibiting lymphocyte apoptosis and reversing monocyte dysfunction
Yan Zhang et al.
CRITICAL CARE (2010)
Genome-wide transcription profiling of human sepsis: a systematic review
Benjamin M. Tang et al.
CRITICAL CARE (2010)
Granulocyte-Macrophage Colony-stimulating Factor to Reverse Sepsis-associated Immunosuppression A Double-Blind, Randomized, Placebo-controlled Multicenter Trial
Christian Meisel et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2009)
IL-7 administration drives T cell-cycle entry and expansion in HIV-1 infection
Irini Sereti et al.
BLOOD (2009)
Prevalence and mortality associated with cytomegalovirus infection in nonimmunosuppressed patients in the intensive care unit
Andre C. Kalil et al.
CRITICAL CARE MEDICINE (2009)
Animal models of sepsis: Why does preclinical efficacy fail to translate to the clinical setting?
Alex Dyson et al.
CRITICAL CARE MEDICINE (2009)
Molecular biology of inflammation and sepsis: A primer
Ismail Cinel et al.
CRITICAL CARE MEDICINE (2009)
Increased circulating regulatory T cells (CD4+CD25+CD127-) contribute to lymphocyte anergy in septic shock patients
Fabienne Venet et al.
INTENSIVE CARE MEDICINE (2009)
The role of T regulatory cells in human sepsis
Aharon Kessel et al.
JOURNAL OF AUTOIMMUNITY (2009)
Sepsis-induced human lymphocyte apoptosis and cytokine production in humanized mice
Jacqueline Unsinger et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2009)
Tilting toward immunosuppression
Richard S. Hotchkiss et al.
NATURE MEDICINE (2009)
MECHANISMS OF DISEASE Cell Death
Richard S. Hotchkiss et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis
Xin Huang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Decrease of CD4-lymphocytes and apoptosis of CD14-monocytes are characteristic alterations in sepsis caused by ventilator-associated pneumonia: results from an observational study
Aimilia Pelekanou et al.
CRITICAL CARE (2009)
The cytokine storm and factors determining the sequence and severity of organ dysfunction in multiple organ dysfunction syndrome
Houli Wang et al.
AMERICAN JOURNAL OF EMERGENCY MEDICINE (2008)
PD-1 and its ligands in tolerance and immunity
Mary E. Keir et al.
ANNUAL REVIEW OF IMMUNOLOGY (2008)
Predictors of 30-day mortality and hospital costs in patients with ventilator-associated pneumonia attributed to potentially antibiotic-resistant Gram-negative bacteria
Katherhie E. Kollef et al.
CHEST (2008)
Downregulation of CD40 Ligand Response in Monocytes from Sepsis Patients
Anna Sinistro et al.
CLINICAL AND VACCINE IMMUNOLOGY (2008)
Randomized, double-blind, placebo-controlled trial of granulocyte colony-stimulating factor in patients with septic shock
Dianne P. Stephens et al.
CRITICAL CARE MEDICINE (2008)
Increased mortality in long-term intensive care patients with active cytomegalovirus infection
Malte Ziemann et al.
CRITICAL CARE MEDICINE (2008)
Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008
R. Phillip Dellinger et al.
CRITICAL CARE MEDICINE (2008)
Apoptosis in sepsis: Mechanisms, clinical impact and potential therapeutic targets
Alfred Ayala et al.
CURRENT PHARMACEUTICAL DESIGN (2008)
Twelve immunotherapy drugs that could cure cancers
Martin A. ‘Mac’ Cheever
IMMUNOLOGICAL REVIEWS (2008)
Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets
Claude Sportes et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2008)
Efficacy and safety of renal tubule cell therapy for acute renal failure
James Tumlin et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2008)
Host-pathogen interactions in sepsis
Tom van der Poll et al.
LANCET INFECTIOUS DISEASES (2008)
Diversity of interferon γ and granulocyte-macrophage colony-stimulating factor in restoring immune dysfunction of dendritic cells and macrophages during polymicrobial sepsis
Stefanie B. Flohe et al.
MOLECULAR MEDICINE (2008)
Immunoparalysis and adverse outcomes from critical illness
W. Joshua Frazier et al.
PEDIATRIC CLINICS OF NORTH AMERICA (2008)
The PD-1/PD-L costimulatory pathway critically affects host resistance to the pathogenic fungus Histoplasma capsulatum
Eszter Lazar-Molnar et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Regulatory T cell populations in sepsis and trauma
Fabienne Venet et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2008)
Role of Toll-like receptor responses for sepsis pathogenesis
Heike Weighardt et al.
IMMUNOBIOLOGY (2007)
Evolving functions of endothelial cells in inflammation
Jordan S. Pober et al.
NATURE REVIEWS IMMUNOLOGY (2007)
Randomized controlled trial of granulocyte colony-stimulating factor for the treatment of severe sepsis due to melioidosis in Thailand
Allen C. Cheng et al.
CLINICAL INFECTIOUS DISEASES (2007)
Chronic sepsis mortality characterized by an individualized inflammatory response
Marcin F. Osuchowski et al.
JOURNAL OF IMMUNOLOGY (2007)
MyD88-dependent expansion of an immature GR-1+ CD11b+ population induces T cell suppression and Th2 polarization in sepsis
Matthew J. Delano et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
Adoptive T cell therapy for cancer in the clinic
Carl H. June
JOURNAL OF CLINICAL INVESTIGATION (2007)
Principles of adoptive T cell cancer therapy
Carl H. June
JOURNAL OF CLINICAL INVESTIGATION (2007)
Involvement of the programmed death-1/programmed death-1 ligand pathway in CD4+CD25+ regulatory T-Cell activity to suppress alloimmune responses
Yusuke Kitazawa et al.
TRANSPLANTATION (2007)
Drotrecogin alfa (activated) in children with severe sepsis: a multicentre phase III randomised controlled trial
Simon Nadel et al.
LANCET (2007)
Multiple triggers of cell death in sepsis: death receptor and mitochondrial-mediated apoptosis
Katherine C. Chang et al.
FASEB JOURNAL (2007)
Surviving sepsis: bcl-2 overexpression modulates splenocyte transcriptional responses in vivo
Tracey H. Wagner et al.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2007)
The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection
Arlene H. Sharpe et al.
NATURE IMMUNOLOGY (2007)
Human CD4+CD25+ regulatory T lymphocytes inhibit lipopolysaccharide-induced monocyte survival through a Fas/Fas ligand-dependent mechanism
Fabienne Venet et al.
JOURNAL OF IMMUNOLOGY (2006)
Mechanisms of mortality in early and late sepsis
Hongyan Xiao et al.
INFECTION AND IMMUNITY (2006)
Safety and efficacy of affinity-purified, anti-tumor necrosis factor-α, ovine fab for injection (CytoFab) in severe sepsis
Todd W. Rice et al.
CRITICAL CARE MEDICINE (2006)
IL-7 administration to humans leads to expansion of CD8+ and CD4+ cells but a relative decrease of CD4+ T-regulatory cells
SA Rosenberg et al.
JOURNAL OF IMMUNOTHERAPY (2006)
Mechanisms of disease - Regulation of immune responses by T cells
H Jiang et al.
NEW ENGLAND JOURNAL OF MEDICINE (2006)
Compartmentalization of the inflammatory response in sepsis and SIRS
Jean-Marc Cavaillon et al.
JOURNAL OF ENDOTOXIN RESEARCH (2006)
Attenuating lymphocyte activity - The crystal structure of the BTLA-HVEM complex
DM Compaan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Memory T cells and their costimulators in human allograft injury
SL Shiao et al.
JOURNAL OF IMMUNOLOGY (2005)
Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death
E Abraham et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
Effect of granulocyte-monocyte colony-stimulating factor therapy on leukocyte function and clearance of serious infection in nonneutropenic patients
AJ Rosenbloom et al.
CHEST (2005)
The many faces of IL-7: From lymphopoiesis to peripheral T cell maintenance
TJ Fry et al.
JOURNAL OF IMMUNOLOGY (2005)
Why do animal models (sometimes) fail to mimic human sepsis?
CT Esmon
CRITICAL CARE MEDICINE (2004)
Optimum treatment of severe sepsis and septic shock: Evidence in support of the recommendations
RA Balk
DM DISEASE-A-MONTH (2004)
Initial clinical results of the bioartificial kidney containing human cells in ICU patients with acute renal failure
HD Humes et al.
KIDNEY INTERNATIONAL (2004)
Akt decreases lymphocyte apoptosis and improves survival in sepsis
U Bommhardt et al.
JOURNAL OF IMMUNOLOGY (2004)
Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab1)2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels
EA Panacek et al.
CRITICAL CARE MEDICINE (2004)
Coupled plasma filtration adsorption
R Bellomo et al.
INTENSIVE CARE MEDICINE (2003)
BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1
N Watanabe et al.
NATURE IMMUNOLOGY (2003)
Multicenter, double-blind, placebo-controlled study of the use of filgrastim in patients hospitalized with pneumonia and severe sepsis
RK Root et al.
CRITICAL CARE MEDICINE (2003)
Impaired production of interferon-γ and tumor necrosis factor-α but not of interleukin 10 in whole blood of patients with sepsis
O Rigato et al.
SHOCK (2003)
Medical progress: The pathophysiology and treatment of sepsis.
RS Hotchkiss et al.
NEW ENGLAND JOURNAL OF MEDICINE (2003)
Autologous Epstein-Barr virus (EBV)-specific cytotoxic T cells for the treatment of persistent active EBV infection
B Savoldo et al.
BLOOD (2002)
A20 inhibits tumor necrosis factor (TNF) alpha-induced apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor I complex in Jurkat T cells
KL He et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Clinical trials of immunomodulatory therapies in severe sepsis and septic shock
JL Vincent et al.
CLINICAL INFECTIOUS DISEASES (2002)
The IKK/NF-kappa B pathway
U Senftleben et al.
CRITICAL CARE MEDICINE (2002)
Overexpression of Bcl-2 in the intestinal epithelium improves survival in septic mice
CM Coopersmith et al.
CRITICAL CARE MEDICINE (2002)
Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care
DC Angus et al.
CRITICAL CARE MEDICINE (2001)
Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans
RS Hotchkiss et al.
JOURNAL OF IMMUNOLOGY (2001)
Lenercept (p55 tumor necrosis factor receptor fusion protein) in severe sepsis and early septic shock: A randomized, double-blind, placebo-controlled, multicenter phase III trial with 1,342 patients
E Abraham et al.
CRITICAL CARE MEDICINE (2001)
Normal responses to injury prevent systemic inflammation and can be immunosuppressive
RS Munford et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2001)
Interleukin 15: biology and relevance to human disease
TA Fehniger et al.
BLOOD (2001)
Pathogenesis and management of multiple organ dysfunction or failure in severe sepsis and septic shock
RA Balk
CRITICAL CARE CLINICS (2000)
Immunologic response to infection and its role in septic shock
LC Casey
CRITICAL CARE CLINICS (2000)
Sepsis after major visceral surgery is associated with sustained and interferon-gamma-resistant defects of monocyte cytokine production
H Weighardt et al.
SURGERY (2000)
Pro- versus anti-inflammatory cytokine profile in patients with severe sepsis: A marker for prognosis and future therapeutic options
CA Gogos et al.
JOURNAL OF INFECTIOUS DISEASES (2000)
A randomized controlled trial of filgrastim for the treatment of hospitalized patients with multilobar pneumonia
S Nelson et al.
JOURNAL OF INFECTIOUS DISEASES (2000)