期刊
VIRULENCE
卷 1, 期 4, 页码 330-332出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/viru.1.4.12364
关键词
heat shock response; Hsf1; Hsp90; transcriptional regulation; fungal pathogenesis; fungal morphogenesis
资金
- BBSRC [BB/F00513X/1, BB/D009308/1, BB/F000111/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/F00513X/1, BB/D009308/1, BB/F000111/1] Funding Source: Medline
- Wellcome Trust [080088] Funding Source: Medline
- Biotechnology and Biological Sciences Research Council [BB/F00513X/1, BB/F000111/1, BB/D009308/1] Funding Source: researchfish
Despite being obligately associated with warm-blooded animals, Candida albicans expresses a bona fide heat shock response that is regulated by the evolutionarily conserved, essential heat shock transcription factor Hsf1. Hsf1 is thought to play a fundamental role in thermal homeostasis, adjusting the levels of essential chaperones to changes in growth temperature, for example in febrile patients. Hsf1 also regulates the expression of Hsp90, which controls the yeast-hypha transition in C. albicans, and we argue, might also control morphogenesis in other fungal pathogens of humans.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据