期刊
CURRENT INFECTIOUS DISEASE REPORTS
卷 18, 期 1, 页码 -出版社
SPRINGER
DOI: 10.1007/s11908-015-0510-9
关键词
Carbapenem-resistant Enterobacteriaceae (CRE); Carbapenemases; KPCs; Pediatrics; Gram-negative; Multidrug-resistant organisms; Resistant gram-negative bacteria
资金
- National Institutes of Health [T32HD060550, K01-AI103028]
- Sherrilyn and Ken Fisher Center for Environmental Infectious Diseases, Division of Infectious Diseases of The Johns Hopkins University School of Medicine
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [T32HD060550] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [K01AI103028] Funding Source: NIH RePORTER
Carbapenem-resistant Enterobacteriaceae (CRE) are an emerging global public health threat. Infections due to CRE are associated with significant morbidity and mortality. Few therapeutic options are available for treatment of these infections, and optimal antibiotic treatment regimens are unclear. Along with the rapidly increasing prevalence of CRE in the USA and worldwide, several studies have described the epidemiology of CRE in the adult population. While CRE are now also reported sporadically in children, there is a significant lack of data on the epidemiology, risk factors, treatment, and outcomes in this population. This article provides a comprehensive review of what is known to date about CRE, including clinical and molecular epidemiology, microbiologic diagnosis, antibiotic treatment options, and outcomes. In particular, this review will focus on the available data on CRE in the pediatric population.
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