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BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2013)
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PHARMACOLOGY & THERAPEUTICS (2013)
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STEM CELLS (2013)
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BREAST CANCER RESEARCH (2013)
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CELLULAR & MOLECULAR IMMUNOLOGY (2012)
Phase I Pharmacologic and Pharmacodynamic Study of the Gamma Secretase (Notch) Inhibitor MK-0752 in Adult Patients With Advanced Solid Tumors
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JOURNAL OF CLINICAL ONCOLOGY (2012)
Noncanonical Notch Signaling Modulates Cytokine Responses of Dendritic Cells to Inflammatory Stimuli
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JOURNAL OF IMMUNOLOGY (2012)
Activation of an IL6 Inflammatory Loop Mediates Trastuzumab Resistance in HER2+Breast Cancer by Expanding the Cancer Stem Cell Population
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MOLECULAR CELL (2012)
A Mutation in EGF Repeat-8 of Notch Discriminates Between Serrate/Jagged and Delta Family Ligands
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SCIENCE (2012)
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SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2012)
Urokinase plasminogen activator receptor induced non-small cell lung cancer invasion and metastasis requires NHE1 transporter expression and transport activity
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Notch-1 signaling facilitates survivin expression in human non-small cell lung cancer cells
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CANCER BIOLOGY & THERAPY (2011)
Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells
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CANCER CELL (2011)
Plasminogen Activator uPA Is a Direct Transcriptional Target of the JAG1-Notch Receptor Signaling Pathway in Breast Cancer
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CANCER RESEARCH (2011)
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Development of Novel Therapeutics Targeting the Urokinase Plasminogen Activator Receptor (uPAR) and Their Translation Toward the Clinic
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CURRENT PHARMACEUTICAL DESIGN (2011)
Noncanonical Notch Function in Motor Axon Guidance Is Mediated by Rac GTPase and the GEF1 Domain of Trio
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DEVELOPMENTAL DYNAMICS (2011)
Phase I Trial of MK-0752 in Children With Refractory CNS Malignancies: A Pediatric Brain Tumor Consortium Study
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JOURNAL OF CLINICAL ONCOLOGY (2011)
Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway
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JOURNAL OF EXPERIMENTAL MEDICINE (2011)
Specific knockdown of uPA/uPAR attenuates invasion in glioblastoma cells and xenografts by inhibition of cleavage and trafficking of Notch-1 receptor
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MOLECULAR CANCER (2011)
Suppression of the uPAR-uPA System Retards Angiogenesis, Invasion, and In Vivo Tumor Development in Pancreatic Cancer Cells
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MOLECULAR CANCER RESEARCH (2011)
High tumor levels of IL6 and IL8 abrogate preclinical efficacy of the γ-secretase inhibitor, RO4929097
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MOLECULAR ONCOLOGY (2011)
Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Activation of Urokinase Plasminogen Activator and Its Receptor Axis Is Essential for Macrophage Infiltration in a Prostate Cancer Mouse Model
Jian Zhang et al.
NEOPLASIA (2011)
Prognostic Impact of Notch Ligands and Receptors in Nonsmall Cell Lung Cancer Coexpression of Notch-1 and Vascular Endothelial Growth Factor-A Predicts Poor Survival
Tom Donnem et al.
CANCER (2010)
Inhibition of Human Breast Cancer Cell Invasion by siRNA Against Urokinase-Type Plasminogen Activator
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CANCER INVESTIGATION (2010)
Notch1 Functions as a Tumor Suppressor in a Model of K-ras-Induced Pancreatic Ductal Adenocarcinoma
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CANCER RESEARCH (2010)
Regulation of Breast Cancer Stem Cell Activity by Signaling through the Notch4 Receptor
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CANCER RESEARCH (2010)
Loss of Rb proteins causes genomic instability in the absence of mitogenic signaling
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GENES & DEVELOPMENT (2010)
Notch and the Skeleton
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MOLECULAR AND CELLULAR BIOLOGY (2010)
Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway
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ONCOGENE (2010)
Mapping the human membrane proteome: a majority of the human membrane proteins can be classified according to function and evolutionary origin
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BMC BIOLOGY (2009)
The Wnt Target Jagged-1 Mediates the Activation of Notch Signaling by Progastrin in Human Colorectal Cancer Cells
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CANCER RESEARCH (2009)
γ-Secretase Inhibitors Abrogate Oxaliplatin-Induced Activation of the Notch-1 Signaling Pathway in Colon Cancer Cells Resulting in Enhanced Chemosensitivity
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CANCER RESEARCH (2009)
Survivin: A new target for anti-cancer therapy
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CANCER TREATMENT REVIEWS (2009)
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
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CELL (2009)
The Notch signaling pathway: Transcriptional regulation at Notch target genes
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CELLULAR AND MOLECULAR LIFE SCIENCES (2009)
Targeted Knockdown of Notch1 Inhibits Invasion of Human Prostate Cancer Cells Concomitant with Inhibition of Matrix Metalloproteinase-9 and Urokinase Plasminogen Activator
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CLINICAL CANCER RESEARCH (2009)
Nrarp Coordinates Endothelial Notch and Wnt Signaling to Control Vessel Density in Angiogenesis
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DEVELOPMENTAL CELL (2009)
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Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Alterations of the Notch pathway in lung cancer
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Metastasis: from dissemination to organ-specific colonization
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NATURE REVIEWS CANCER (2009)
Autocrine IL-6 signaling: A key event in tumorigenesis?
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CANCER CELL (2008)
Notch Signaling Regulates Mammary Stem Cell Function and Luminal Cell-Fate Commitment
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CELL STEM CELL (2008)
Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells
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CELL STEM CELL (2008)
Notch signaling in embryonic and adult myelopoiesis
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CELLS TISSUES ORGANS (2008)
Targeting the most upstream site of Wnt signaling pathway provides a strategic advantage for therapy in colorectal cancer
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CURRENT DRUG TARGETS (2008)
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DEVELOPMENT (2008)
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DEVELOPMENTAL BIOLOGY (2008)
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JOURNAL OF CELL BIOLOGY (2008)
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JOURNAL OF CLINICAL ONCOLOGY (2008)
Prostate cancer stem cells: A new target for therapy
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JOURNAL OF CLINICAL ONCOLOGY (2008)
New wirings in the survivin networks
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ONCOGENE (2008)
IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland
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JOURNAL OF CLINICAL INVESTIGATION (2007)
Effects of recombinant erythropoietin on breast cancer-initiating cells
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NEOPLASIA (2007)
Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin
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JOURNAL OF EXPERIMENTAL MEDICINE (2007)
Cancer stem cells in solid tumors
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CURRENT OPINION IN BIOTECHNOLOGY (2007)
γ-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers
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CANCER RESEARCH (2007)
The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia
Benjamin J. Thompson et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
Hypoxia-inducible factors, stem cells, and cancer
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CELL (2007)
Notch signaling in development and cancer
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Notch signaling and its role in breast cancer
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FRONTIERS IN BIOSCIENCE-LANDMARK (2007)
The Hes gene family: repressors and oscillators that orchestrate embryogenesis
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GENES & DEVELOPMENT (2007)
Association of the circulating levels of the urokinase system of plasminogen activation with the presence of prostate cancer and invasion, progression, and metastasis
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JOURNAL OF CLINICAL ONCOLOGY (2007)
Identification of pancreatic cancer stem cells
Chenwei Li et al.
CANCER RESEARCH (2007)
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NATURE (2007)
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Devon A. Lawson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Notch signaling, gamma-secretase inhibitors, and cancer therapy
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CANCER RESEARCH (2007)
Networking of WNT, FGF, notch, BMP, and hedgehog signaling pathways during carcinogenesis
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STEM CELL REVIEWS (2007)
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Gillian Farnie et al.
STEM CELL REVIEWS (2007)
Cell and molecular biology of Notch
Ulla-Maj Fiuza et al.
JOURNAL OF ENDOCRINOLOGY (2007)
Overexpression of the NOTCH1 intracellular domain inhibits cell proliferation and alters the neuroendocrine phenotype of medullary thyroid cancer cells
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JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Jagged 1 is a β-catenin target gene required for ectopic hair follicle formation in adult epidermis
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Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc
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MOLECULAR AND CELLULAR BIOLOGY (2006)
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Notch1 promotes survival of E2A-deficient T cell lymphomas through pre-T cell receptor-dependent and -independent mechanisms
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BLOOD (2006)
Notch1 signaling promotes primary melanoma progression by activating mitogen-activated protein kinase/phosphatidylinositol 3-kinase-Akt pathways and up-regulating N-cadherin expression
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CANCER RESEARCH (2006)
Notch 1 overexpression inhibits osteoblastogenesis by suppressing Wnt/β-catenin but not bone morphogenetic protein signaling
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JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
被撤回的出版物: Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells (Retracted article. See vol. 17, pg. 2268, 2018)
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MOLECULAR CANCER THERAPEUTICS (2006)
Aberrant activation of Notch signaling in human breast cancer
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CANCER RESEARCH (2006)
NOTCH signaling as a novel cancer therapeutic target
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CURRENT CANCER DRUG TARGETS (2006)
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Hairy Enhancer of Split-1 (HES-1) a Notch1 effector, inhibits the growth of carcinoid tumor cells
M Kunnimalaiyaan et al.
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CANCER RESEARCH (2005)
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JOURNAL OF CLINICAL INVESTIGATION (2005)
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EUROPEAN JOURNAL OF CANCER (2005)
High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival
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CANCER RESEARCH (2005)
The interplay between DSL proteins and ubiquitin ligases in Notch signaling
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DEVELOPMENT (2005)
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Toward an understanding of the physiological function of mammalian stem cells
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DEVELOPMENTAL CELL (2005)
Regulation of neuroendocrine differentiation in gastrointestinal carcinoid tumor cells by notch signaling
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JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2005)
Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
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NATURE (2005)
P21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation
V Devgan et al.
GENES & DEVELOPMENT (2005)
Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation
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BLOOD (2005)
Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion
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NATURE CELL BIOLOGY (2005)
Inducible inactivation of Notch1 causes nodular regenerative hyperplasia in mice
A Croquelois et al.
HEPATOLOGY (2005)
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YX Wang et al.
LANCET (2005)
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JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
The urokinase plasminogen activator system: Role in malignancy
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CURRENT PHARMACEUTICAL DESIGN (2004)
LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis
J Galceran et al.
GENES & DEVELOPMENT (2004)
Notch1 and Notch2 have opposite effects on embryonal brain tumor growth
X Fan et al.
CANCER RESEARCH (2004)
Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis
S Pece et al.
JOURNAL OF CELL BIOLOGY (2004)
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
AP Weng et al.
SCIENCE (2004)
Modulation of notch signaling by mastermind-like (MAML) transcriptional co-activators and their involvement in tumorigenesis
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SEMINARS IN CANCER BIOLOGY (2004)
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JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Osteoblastic cells regulate the haematopoietic stem cell niche
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NATURE (2003)
Prospective identification of tumorigenic breast cancer cells
M Al-Hajj et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Notch1 functions as a tumor suppressor in mouse skin
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NATURE GENETICS (2003)
HES and HERP families: Multiple effectors of the Notch signaling pathway
T Iso et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2003)
Circulating interleukin-6 predicts survival in patients with metastatic breast cancer
R Salgado et al.
INTERNATIONAL JOURNAL OF CANCER (2003)
Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors
L Wu et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
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GENES & DEVELOPMENT (2002)
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NATURE (2001)
Induction of cyclin D1 transcription and CDK2 activity by Notchic:: Implication for cell cycle disruption in transformation by Notchic
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MOLECULAR AND CELLULAR BIOLOGY (2001)
Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation
A Rangarajan et al.
EMBO JOURNAL (2001)
MAML1, a human homologue of Drosophila Mastermind, is a transcriptional co-activator for NOTCH receptors
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NATURE GENETICS (2000)
A novel proteolytic cleavage involved in Notch signaling:: The role of the disintegrin-metalloprotease TACE
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MOLECULAR CELL (2000)
A ligand-induced extracellular cleavage regulates γ-secretase-like proteolytic activation of Notch1
JS Mumm et al.
MOLECULAR CELL (2000)
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