期刊
CURRENT HIV/AIDS REPORTS
卷 12, 期 1, 页码 33-40出版社
SPRINGER
DOI: 10.1007/s11904-014-0246-4
关键词
HIV; SIV; Memory T cell; T memory stem cell; HIV-1 reservoir; Persistence; Central memory; Effector memory; Stem cell; beta-Catenin
资金
- American Foundation for AIDS Research [108905-56-RGRL, 108302-51-RGRL]
- NICHD Child Health Research Career Development Award [K12 HD072245]
- Doris Duke Charitable Foundation [2009034]
- NIH grant [AI098487, AI106468, R37AI066998]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI098487, R37AI066998, R21AI106468, R01AI066998] Funding Source: NIH RePORTER
- OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [P51OD011132] Funding Source: NIH RePORTER
In analogy to many tissues in which mature, terminally differentiated cells are continuously replenished by the progeny of less differentiated, long-lasting stem cells, it has been suspected that memory T lymphocytes might contain small numbers of stem cell-like cells. However, only recently have such cells been physically identified and isolated from humans, mice, and nonhuman primates. These cells, termed T memory stem cells (T-SCM), represent approximately 2-4% of all circulating T lymphocytes, seem to be extremely durable, and can rapidly differentiate into more mature central memory, effector memory, and effector T cells, while maintaining their own pool size through homeostatic self-renewal. Although it is becoming increasingly evident that that these cells have critical roles for T cell homeostasis and maintaining life-long cellular immunity against microbial pathogens during physiological conditions, they also seem intrinsically involved in many key aspects of HIV/SIV disease pathogenesis. Current data suggest that CD4+T-SCM cells represent a core element of the HIV-1 reservoir in patients treated with suppressive antiretroviral therapy (ART) and that relative resistance of CD4+ T-SCM cells to SIV represents a distinguishing feature of non-pathogenic SIV infection in natural hosts. This article summarizes recent studies investigating the role of T-SCM in HIV/SIV infection.
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