期刊
THERANOSTICS
卷 4, 期 3, 页码 240-255出版社
IVYSPRING INT PUBL
DOI: 10.7150/thno.6914
关键词
Non-viral; Gene delivery; Vectors; Chemical Methods
资金
- National Key Program for Developing Basic Research of China [2010CB933903, 2014CB744501]
- NSFC [61271056, 31201003]
- Hunan Science and Technology Projects [2012SK3105]
- Scientific Research Fund of Hunan Provincial Education Department [11A030]
- China Postdoctoral Science Foundation [20100471362, 2012M520980, 2012M511660]
- Jiangsu Postdoctoral Science Foundation [1301093C]
- State Key Laboratory of Bio-electronics, Southeast University, China [2013G10]
- Economical Forest Cultivation and Utilization of 2011 Collaborative Innovation Center in Hunan Province
Gene transfer methods are promising in the field of gene therapy. Current methods for gene transfer include three major groups: viral, physical and chemical methods. This review mainly summarizes development of several types of chemical methods for gene transfer in vitro and in vivo by means of nano-carriers like; calcium phosphates, lipids, and cationic polymers including chitosan, polyethylenimine, polyamidoamine dendrimers, and poly(lactide-co-glycolide). This review also briefly introduces applications of these chemical methods for gene delivery.
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