期刊
THERANOSTICS
卷 4, 期 8, 页码 834-844出版社
IVYSPRING INT PUBL
DOI: 10.7150/thno.9199
关键词
smart nanoparticles; alternating current magnetic field; cancer cells
资金
- Japan Society for the Promotion of Science (JSPS) [26709050, 24760551]
- Adaptable and Seamless Technology Transfer Program (A-STEP) through target-driven R&D (Exploratory Research), JST [AZ251Z00996M]
We report the synthesis of smart nanoparticles (NPs) that generate heat in response to an alternating current magnetic field (ACMF) and that sequentially release an anticancer drug (doxorubicin, DOX). We further study the in vivo therapeutic efficacy of the combination of magnetic hyperthermia (MHT) and chemotherapy using the smart NPs for the treatment of multiple myeloma. The smart NPs are composed of a polymer with a glass-transition temperature (Tg) of 44 degrees C, which contains clustered Fe3O4 NPs and DOX. The clustered Fe3O4 NPs produce heat when the ACMF is applied and rise above 44 degrees C, which softens the polymer phase and leads to the release of DOX. The combination of MHT and chemotherapy using the smart NPs destroys cancer cells in the entire tumor and achieves a complete cure in one treatment without the recurrence of malignancy. Furthermore, the smart NPs have no significant toxicity.
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