期刊
THERANOSTICS
卷 4, 期 4, 页码 399-411出版社
IVYSPRING INT PUBL
DOI: 10.7150/thno.8171
关键词
Hierarchical micelles; Photothermal therapy; Singlet oxygen; Synergistic therapy; Cancer eradication
资金
- National Natural Science Foundation of China [81202472, 51273165]
- National Basic Research Program [2012CB932500, 2013CB733802]
- priority academic program development of Jiangsu higher education institutions (PAPD)
It is highly desirable to develop theranostic nanoparticles for achieving cancer imaging with enhanced contrast and simultaneously multimodal synergistic therapy. Herein, we report a theranostic micelle system hierarchically assembling cyanine dye (indocyanine green) and chemotherapeutic compound (doxorubicin) (I/D-Micelles) as a novel theranostic platform with high drug loading, good stability and enhanced cellular uptake via clathrin-mediated endocytosis. I/D-Micelles exhibit the multiple functionalities including near-infrared fluorescence (NIRF), hyperthermia and intracellular singlet oxygen from indocyanine green, and simultaneous cytotoxicity from doxorubicin. Upon photoirradiation, I/D-Micelles can induce NIRF imaging, acute photothermal therapy via hyperthermia and simultaneous synergistic chemotherapy via singlet oxygen- triggered disruption of lysosomal membranes, eventually leading to enhanced NIRF imaging and superior tumor eradication without any re-growth. Our results suggest that the hierarchical micelles can act as a superior theranostic platform for cancer imaging and multimodal synergistic therapy.
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