期刊
THERANOSTICS
卷 4, 期 11, 页码 1133-1144出版社
IVYSPRING INT PUBL
DOI: 10.7150/thno.9945
关键词
Microbubble; Liposome; Ultrasound imaging; Drug and gene delivery; Theranostics
资金
- National Research Foundation of Korea [2010-0008846, 2010-0009271]
- O-song Medical Innovation Foundation R&D project of Ministry of Health and Welfare in South Korea [HO13C0009]
- National Institute of Health [R01-HL113156]
- Seoul National University Hospital [04-2012-0670]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL113156] Funding Source: NIH RePORTER
Theranostic agents present a promising clinical approach for cancer detection and treatment. We herein introduce a microbubble and liposome complex (MB-Lipo) developed for ultrasound (US) imaging and activation. The MB-Lipo particles have a hybrid structure consisting of a MB complexed with multiple Lipos. The MB components are used to generate high echo signals in US imaging, while the Lipos serve as a versatile carrier of therapeutic materials. MB-Lipo allows high contrast US imaging of tumor sites. More importantly, the application of high acoustic pressure bursts MBs, which releases therapeutic Lipos and further enhances their intracellular delivery through sonoporation effect. Both imaging and drug release could thus be achieved by a single US modality, enabling in situ treatment guided by real-time imaging. The MB-Lipo system was applied to specifically deliver anti-cancer drug and genes to tumor cells, which showed enhanced therapeutic effect. We also demonstrate the clinical potential of MB-Lipo by imaging and treating tumor in vivo.
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