期刊
THERANOSTICS
卷 4, 期 5, 页码 534-545出版社
IVYSPRING INT PUBL
DOI: 10.7150/thno.8188
关键词
Au cubic nano aggregates; near-infrared absorption; theranostics; photothermal therapy; photoacoustic imaging
资金
- National Key Basic Research Program of China [2013CB933901, 2014CB744502]
- National Natural Science Foundation of China [21222106, 81370042, 81000662, 81201805]
- Natural Science Foundation of Fujian [2013J06005, 2013D014]
- Program for New Century Excellent Talents in University [NCET-10-0709]
- Projects of Xiamen Science and Technology Program [3502Z20130030]
Multifunctional nanostructures combining diagnosis and therapy modalities into one entity have drawn much attention in the biomedical applications. Herein, we report a simple and cost-effective method to synthesize a novel cubic Au nano-aggregates structure with edge-length of 80 nm (Au-80 CNAs), which display strong near-infrared (NIR) absorption, excellent water-solubility, good photothermal stability, and high biocompatibility. Under 808 nm laser irradiation for 5 min, the temperature of the solution containing Au-80 CNAs (100 mu g/ mL) increased by similar to 38 C. The in vitro and in vivo studies demonstrated that Au-80 CNAs could act as both photothermal therapeutic (PTT) agents and photoacoustic imaging (PAI) contrast agents, indicating that the only one nano-entity of Au-80 CNAs shows great potentials for theranostic applications. Moreover, this facile and cost-effective synthetic method provides a new strategy to prepare stable Au nanomaterials with excellent optical properties for biomedical applications.
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