期刊
THERANOSTICS
卷 3, 期 3, 页码 167-180出版社
IVYSPRING INT PUBL
DOI: 10.7150/thno.5716
关键词
Gold nanoparticles; multifunctional nanocomposites; immunoassay; DNA detection; cell bioimaging; mycobacteria; Azospirillum brasilense; photodynamic and photothermal therapy; placental barrier; materno-embryonic transfer of gold nanoparticles
资金
- Russian Foundation for Basic Research
- Programs of the Presidium of the Russian Academy of Sciences Basic Sciences for Medicine and Basic Technologies for Nanostructures and Nanomaterials
- Government of the Russian Federation
- President of the Russian Federation
- Bortnik Foundation grant UMNIK
Gold nanoparticles (GNPs) and GNP-based multifunctional nanocomposites are the subject of intensive studies and biomedical applications. This minireview summarizes our recent efforts in analytical and theranostic applications of engineered GNPs and nanocomposites by using plasmonic properties of GNPs and various optical techniques. Specifically, we consider analytical biosensing; visualization and bioimaging of bacterial, mammalian, and plant cells; photodynamic treatment of pathogenic bacteria; and photothermal therapy of xenografted tumors. In addition to recently published reports, we discuss new data on dot immunoassay diagnostics of mycobacteria, multiplexed immunoelectron microscopy analysis of Azospirillum brasilense, materno-embryonic transfer of GNPs in pregnant rats, and combined photodynamic and photothermal treatment of rat xenografted tumors with gold nanorods covered by a mesoporous silica shell doped with hematoporphyrin.
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