期刊
THERANOSTICS
卷 2, 期 3, 页码 271-282出版社
IVYSPRING INT PUBL
DOI: 10.7150/thno.3618
关键词
Carbon nanotubes; pharmacokinetics; metabolism; toxicity; biomedical applications
资金
- China Ministry of Science and Technology [2011CB933402]
- China Natural Science Foundation [21071094]
- Shanghai Municipal Education Committee [11ZZ82]
- Chinese Ministry of Education [211053]
- Southwest University for Nationalities [11NZYBS06]
Carbon nanotubes (CNTs) have attracted great interest of the nano community and beyond. However, the biomedical applications of CNTs arouse serious concerns for their unknown in vivo consequence, in which the information of pharmacokinetics, metabolism and toxicity of CNTs is essential. In this review, we summarize the updated data of CNTs from the biomedical view. The information shows that surface chemistry is crucial in regulating the in vivo behaviors of CNTs. Among the functionalization methods, PEGylation is the most efficient one to improve the pharmacokinetics and biocompatibility of CNTs. The guiding effects of the pharmacokinetics, metabolism and toxicity information on the biomedical applications of CNTs are discussed.
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