期刊
THERANOSTICS
卷 2, 期 7, 页码 723-733出版社
IVYSPRING INT PUBL
DOI: 10.7150/thno.4275
关键词
Phospholipid; Micelle encapsulation; quantum dots; bioimaging; PEG
资金
- Nanyang Technological University [M4080141.040]
- Tier 1 Academic Research Funds from Singapore Ministry of Education and partially from the Singapore Ministry of Ed ucation under Tier 2 Research Grant [M4010360.040 RG29/10, MOE2010-T2-2-010 (M4020020.040 ARC2/11)]
Surface modification and functionalization of bioconjugated quantum dots (QDs) has drawn great attention for the past few years due to their wide applications in biomedical research. In this contribution, we demonstrate the use of PEGylated phospholipid micelles to encapsulate near infrared emitting ultra-small lead sulfide (PbS) QDs for in vitro and in vivo imaging. The cytotoxicity of the micelle-encapsulated QDs formulation was evaluated using MTS assay and histological analysis studies. We have found that upon encapsulating the QDs with phospholipid micelle, the toxicity of the PbS QDs is reduced, from which we envision that the PEGylated phospholipid micelle-encapsulated PbS QDs formulation can be used as theranostics probes for some selected applications in cell imaging and small animals study.
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