期刊
STEM CELL RESEARCH & THERAPY
卷 4, 期 -, 页码 -出版社
BMC
DOI: 10.1186/scrt371
关键词
microphysiological system; skeletal muscle myoblasts; tissue-engineered blood vessel; contractile force; oxygen gradients; differentiation
资金
- National Institutes of Health Common Fund for the Microphysiological Systems Initiative and Darwin Prockop (NIH) [P40 RR017447]
- [R01AR055226]
- [R21AR055195]
- [UH2TR000505]
Microphysiological systems provide a tool to simulate normal and pathological function of organs for prolonged periods. These systems must incorporate the key functions of the individual organs and enable interactions among the corresponding microphysiological units. The relative size of different microphysiological organs and their flow rates are scaled in proportion to in vivo values. We have developed a microphysiological three-dimensional engineered human skeletal muscle system connected to a circulatory system that consists of a tissue-engineered blood vessel as part of a high-pressure arterial system. The engineered human skeletal muscle tissue reproduces key mechanical behaviors of skeletal muscle in vivo. Pulsatile flow is produced using a novel computer-controlled magnetically activated ferrogel. The system is versatile and the muscle unit can be integrated with other organ systems. Periodic monitoring of biomechanical function provides a non-invasive assessment of the health of the tissue and a way to measure the response to drugs and toxins.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据