期刊
SOCIAL SCIENCE & MEDICINE
卷 74, 期 1, 页码 67-74出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.socscimed.2011.09.036
关键词
Epigenetics; Social environment; Psychiatric disorders; Methylation
资金
- Japan Society for the Promotion of Science [ITP2007201210]
- NIH [DA 022720, DA 022720-S1, MH088283, MH 082729]
- [MH093612]
- [MH078928]
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH082729, RC1MH088283, R01MH078928, R01MH093612] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA022720] Funding Source: NIH RePORTER
The social environment plays a considerable role in determining major psychiatric disorders. Emerging evidence suggests that features of the social environment modify gene expression independently of the primary DNA sequence through epigenetic processes. Accordingly, dysfunction of epigenetic mechanisms offers a plausible mechanism by which an adverse social environment gets into the mind and results in poor mental health. The purpose of this review is to provide an overview of the studies suggesting that epigenetic changes introduced by the social environment then manifest as psychological consequences. Our goal is to build a platform to discuss the ways in which,future epidemiologic studies may benefit from including epigenetic measures. We focus on schizophrenia, major depressive disorder, posttraumatic stress disorder, anorexia nervosa, and substance dependence as examples that highlight the ways in which social environmental exposures, mediated through epigenetic processes, affect mental health. (C) 2011 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据