期刊
SCIENTIFIC REPORTS
卷 8, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-018-33690-7
关键词
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资金
- Japan Science and Technology Agency, Exploratory Research for Advanced Technology, AMED [JP18gm0010002h0103]
- Japan Society for the Promotion of Science, KAKENHI [17K08623]
- Research grant for Type 1 diabetes, Japan Insulin-Dependent Diabetes Mellitus Network
- California Institute for Regenerative Medicine
- Grants-in-Aid for Scientific Research [17K08623] Funding Source: KAKEN
To study development of the conceptus in xenogeneic environments, we assessed interspecies chimera formation as well as tetraploid complementation between mouse and rat. Overall contribution of donor PSC-derived cells was lower in interspecies chimeras than in intraspecies chimeras, and high donor chimerism was associated with anomalies or embryonic death. Organ to organ variation in donor chimerism was greater in interspecies chimeras than in intraspecies chimeras, suggesting species-specific affinity differences among interacting molecules necessary for organogenesis. In interspecies tetraploid complementation, embryo development was near normal until the stage of placental formation, after which no embryos survived.
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