期刊
SCIENTIFIC REPORTS
卷 8, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-018-30991-9
关键词
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资金
- Hong Kong Baptist University [FRG2/16-17/007, FRG2/17-18/003]
- Health and Medical Research Fund [HMRF/14150561]
- Research Grants Council [HKBU/12301115]
- National Natural Science Foundation of China [21575121, 21775131, 21628502]
- Hong Kong Baptist University Century Club Sponsorship Scheme 2018
- Interdisciplinary Research Matching Scheme [RC-IRMS/15-16/03]
- Innovation and Technology Fund [ITS/260/16FX]
- Collaborative Research Fund [C5026-16G]
- Matching Proof of Concept Fund [MPCF-001-2017/18]
- Science and Technology Development Fund
- Macao SAR [077/2016/A2]
- University of Macau [MYRG2016-00151-ICMS-QRCM]
- Natural Science Foundation of Jiangxi Province [20171BAB213008]
Nitric oxide (NO) is an intra- and extracellular messenger with important functions during human physiology process. A long-lived luminescent iridium(III) complex probe 1 has been designed and synthesized for the monitoring of NO controllably released from sodium nitroprusside (SNP). Probe 1 displayed a 15-fold switch-on luminescence in the presence of SNP at 580 nm. The probe exhibited a linear response towards SNP between 5 to 25 mu M with detection limit at 0.18 mu M. Importantly, the luminescent switch-on detection of NO in HeLa cells was demonstrated. Overall, complex 1 has the potential to be applied for NO tracing in complicated cellular environment.
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