期刊
SCIENTIFIC REPORTS
卷 7, 期 -, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41598-017-15264-1
关键词
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资金
- Monash University
- National Heart Foundation [100864]
- National Health and Medical Research Council (NHMRC) [APP1047897]
- NHMRC [APP490977]
In-vitro studies suggest that vitamin D reduces inflammation by inhibiting nuclear factor kappa-B (NF kappa B) activity. Yet, no trials have examined the effects of vitamin D supplementation on NF kappa B activity in-vivo in humans. We conducted a double-blind randomized trial (RCT) examining effects of vitamin D supplementation on inflammatory markers and NF kappa B activity in peripheral blood mononuclear cells (PBMCs). Sixty-five overweight/obese, vitamin D-deficient (25-hydroxyvitamin D [25(OH) D] <= 50 nmol/L) adults were randomized to a single 100,000 IU bolus followed by 4,000 IU daily cholecalciferol or matching placebo for 16 weeks. We measured BMI, % body fat, serum 25(OH) D, high-sensitivity C-reactive protein (hsCRP), tumour necrosis factor (TNF), monocyte chemoattractant protein-1 (MCP-1), interferon-gamma (IFN-gamma), several interleukins, and NF kappa B activity in PBMCs. Fifty-four participants completed the study. Serum 25(OH) D concentrations increased with vitamin D supplementation compared to placebo (p < 0.001). Vitamin D and placebo groups did not differ in any inflammatory markers or NF kappa B activity (all p > 0.05). Results remained non-significant after adjustment for age, sex, and % body fat, and after further adjustment for sun exposure, physical activity, and dietary vitamin D intake. Although in-vitro studies report anti-inflammatory effects of vitamin D, our RCT data show no effect of vitamin D supplementation on inflammatory markers or NF kappa B activity in-vivo in humans.
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