期刊
CANCER IMMUNOLOGY RESEARCH
卷 4, 期 1, 页码 26-32出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/2326-6066.CIR-15-0154
关键词
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资金
- Swiss National Science Foundation [310030_146130, 316030_150768]
- Swiss Cancer League
- University research priority project URPP-translational cancer research
- European Union FP7 project ATECT
- EU-FP7-ITN_NeuroKine
- DFG grant [HO 4440/1-1]
- EMBO long-term fellowship [ALTF 508-2011]
The role of the IL23/IL17A axis in tumor-immune interactions is a matter of controversy. Although some suggest that IL17A-producing T cells (T(H)17) can suppress tumor growth, others report that IL17A and IL23 accelerate tumor growth. Here, we systematically assessed the impact of IL17A-secreting lymphocytes in several murine models of tumor lung metastasis. Genetic fate mapping revealed that IL17A was secreted within lung metastases predominantly by gamma delta T cells, whereas TH17 cells were virtually absent. Using different tumor models, we found Il17a(-/-) mice to consistently develop fewer pulmonary tumor colonies. IL17A specifically increased blood vessel permeability and the expression of E-selectin and VCAM-1 by lung endothelial cells in vivo. In transgenic mice, specific targeting of IL17A to the endothelium increased the number of tumor foci. Moreover, the direct impact of IL17A on lung endothelial cells resulted in impaired endothelial barrier integrity, showing that IL17A promotes the formation of lung metastases through tumor-endothelial transmigration. (C) 2015 AACR.
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