期刊
BIOLOGY OF SEX DIFFERENCES
卷 6, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s13293-015-0037-7
关键词
Sjogren's syndrome; Sex differences; Autoimmune disease; Inflammation; Autoantibodies; Lymphoma
资金
- National Institutes of Health [R01 HL111938, R21 ES024414]
- American Heart Association [GIA 12050000]
- Sapienza University of Rome
- US-Italy Fulbright Commission
Autoimmune diseases (ADs) are estimated to affect between 5 and 8 % of the US population, and approximately 80 % of these patients are women. Sjogren's syndrome (SS) is an AD that occurs predominately in women over men (16: 1). The hallmark characteristic of SS is diminished secretory production from the primary exocrine gland and the lacrimal or salivary glands resulting in symptoms of dry eye and mouth. The disease is believed to be mediated by an inflammatory and autoantibody response directed against salivary and lacrimal gland tissues. This review will examine the literature on sex differences in the immune response of patients and animal models of Sjogren's syndrome in order to gain a better understanding of disease pathogenesis.
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