期刊
SCIENTIFIC REPORTS
卷 7, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-017-11960-0
关键词
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资金
- Portuguese Foundation for Science and Technology (FCT) [PTDC/SAU-NEU/103728/2008, PTDC/NEU-NMC/0205/2012, UID/NEU/04539/2013, SFRH/BPD/78187/2011-JC, SFRH/BD/88419/2012-CS, SFRH/BD/80577/2011-MM, IF/00638/2014]
- FCT
- FEDER - Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020 - Operational Programme for Competitiveness and Internationalisation (POCI), Portugal 2020
- Portuguese funds through FCT-Fundacao para a Ciencia e a Tecnologia/Ministerio da Ciencia, Tecnologia e Inovacao in the framework of the project Institute for Research and Innovation in Health Sciences [POCI-01-0145-FEDER-007274]
- FCT/MEC through National Funds
- FEDER via the PT2020 Partnership Agreement under the 4293 Unit ID
- QREN (Quadro de Referencia Estrategica Nacional)
- National Mass Spectrometry Network (RNEM) [REDE/1506/REM/2005]
- Fundação para a Ciência e a Tecnologia [PTDC/SAU-NEU/103728/2008] Funding Source: FCT
Intervertebral disc (IVD) degeneration is often the cause of low back pain. Degeneration occurs with age and is accompanied by extracellular matrix (ECM) depletion, culminating in nucleus pulpous (NP) extrusion and IVD destruction. The changes that occur in the disc with age have been under investigation. However, a thorough study of ECM profiling is needed, to better understand IVD development and age-associated degeneration. As so, iTRAQ LC-MS/MS analysis of foetus, young and old bovine NPs, was performed to define the NP matrisome. The enrichment of Collagen XII and XIV in foetus, Fibronectin and Prolargin in elder NPs and Collagen XI in young ones was independently validated. This study provides the first matrisome database of healthy discs during development and ageing, which is key to determine the pathways and processes that maintain disc homeostasis. The factors identified may help to explain age-associated IVD degeneration or constitute putative effectors for disc regeneration.
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