期刊
BIOLOGY OPEN
卷 4, 期 9, 页码 1206-1212出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/bio.010215
关键词
EGCG; SEVI; PAP85-120; SEM1; SEM2; HIV infectivity
类别
资金
- National Science Foundation (NSF) [DGE-0822]
- Howard Hughes Medical Institute (HHMI) grant
- Bill and Melinda Gates Foundation Grand Challenges Explorations Award
- Linda Pechenik Montague Investigator Award
- National Institutes of Health (NIH) [R21HD074510]
Semen harbors amyloid fibrils formed by proteolytic fragments of prostatic acid phosphatase (PAP248-286 and PAP85-120) and semenogelins (SEM1 and SEM2) that potently enhance HIV infectivity. Amyloid but not soluble forms of these peptides enhance HIV infection. Thus, agents that remodel these amyloid fibrils could prevent HIV transmission. Here, we confirm that the green tea polyphenol, epigallocatechin-3-gallate (EGCG), slowly remodels fibrils formed by PAP248-286 termed SEVI (semen derived enhancer of viral infection) and also exerts a direct anti-viral effect. We elucidate for the first time that EGCG remodels PAP85-120, SEM1(45-107), and SEM2(49-107) fibrils more rapidly than SEVI fibrils. We establish EGCG as the first small molecule that can remodel all four classes of seminal amyloid. The combined anti-amyloid and anti-viral properties of EGCG could have utility in preventing HIV transmission.
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