期刊
SCIENTIFIC REPORTS
卷 7, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-017-09227-9
关键词
-
资金
- Health and Family Planning Commission of Hunan Province, China [2015/43, B2016060, B2017099]
- National Health and Family Planning Commission of China [2013/544]
To investigate the usefulness of intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) in discriminating the pathological complete response (pCR) to neoadjuvant chemoradiotherapy (nCRT) in locally advanced rectal cancer (LARC), 42 patients underwent preoperative IVIM-DWI before (pre-nCRT) and after nCRT (post-nCRT). The values of pre-nCRT and post-nCRT IVIM-DWI parameters (ADC, D, D* and f), together with the percentage changes (Delta% parametric value) induced by nCRT, were compared between the pCR (tumour regression grade [TRG] 4) and non-pCR (TRG 0, 1, 2 or 3) groups and between the GR (TRG 3 or 4) and PR (TRG 0, 1 or 2) groups based on the Dworak TRG system. After nCRT, the ADC and D values for LARC increased significantly (all P < 0.05). The TRG score revealed a positive correlation with pref (r = 0.357, P = 0.020), postD (r = 0.551, P < 0.001) and Delta% D (r = 0.605, P < 0.001). The pCR group (n = 10) had higher preD*, pref, postD, Delta% ADC and Delta.% D values than the non-pCR group (n = 32) (all P < 0.05). The GR group (n = 15) exhibited higher postD, Delta% ADC and Delta% D values than the PR group (n = 27) (all P < 0.05). Based on ROC analysis, Delta% D had a higher area under the curve value than Delta% ADC (P = 0.009) in discriminating the pCR from non-pCR groups. In conclusion, IVIM-DWI may be helpful in identifying the pCR to nCRT for LARC and is more accurate than traditional DWI.
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