期刊
SCIENTIFIC REPORTS
卷 7, 期 -, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41598-017-00850-0
关键词
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资金
- Duke Cancer Institute, P30 Cancer Center Support Grant [NIH CA014236]
- Duke Cancer Institute, Duke University Medical Center
- Transdisciplinary Research in Cancer of the Lung (TRICL) Study
- Genetic Associations and Mechanisms in Oncology (GAME-ON) Network [U19-CA148127]
- Canadian Cancer Society Research Institute [020214]
- Ontario Institute of Cancer and Cancer Care Ontario Chair Award
- Cancer Research UK (Bobby Moore Fund) [C1298/A8780, C1298/A8362]
- NCRN
- HEAL
- Sanofi-Aventis
- NIH [5R01CA055769, 5R01CA127219, 5R01CA133996, 5R01CA121197, U19CA148127, R01 CA111703, UO1 CA63673]
- The Roy Castle Lung Cancer Foundation, UK
- Deutsche Krebshilfe [70-2919]
- Helmholtz-DAAD fellowship [A/07/97379]
- GSF
- German Federal Ministry of Education, Science, Research and Technology
- State of Bavaria
- National Genome Research Network (NGFN)
- DFG [BI576/2-1, BI576/2-2]
- Helmholtzgemeinschaft (HGF)
- Federal office for Radiation Protection [BfS: STSch4454]
- Norwegian Cancer Association
- Functional Genomics Programme of Research Council of Norway
- US National Cancer Institute
- Fred Hutchinson Cancer Research Center
- US National Cancer Institute [R01 CA092039]
- FP7 grant [REGPOT245536]
- Estonian Government [SF0180142s08]
- EU RDF
- University of Tartu [SP1GVARENG]
- IARC
- Intramural Research Program of NIH
- NCI [NO1-CN-25514]
- Division of Cancer Epidemiology and Genetics
- US Public Health Service contracts from the NCI [N01-CN-45165, N01-RC-45035, N01-RC-37004]
- Georgetown University [NO1-CN-25522]
- Pacific Health Research Institute [NO1-CN-25515]
- Henry Ford Health System [NO1-CN-25512]
- University of Minnesota [NO1-CN-25513]
- Washington University [NO1-CN-25516]
- University of Pittsburgh [NO1-CN-25511]
- University of Utah [NO1-CN-25524]
- Marshfield Clinic Research Foundation [NO1-CN-25518]
- University of Alabama at Birmingham [NO1-CN-75022]
- University of California, Los Angeles [NO1-CN-25404]
- American Cancer Society
- The NIH Genes, Environment and Health Initiative (GEI) [HG-06-033-NCI-01, RO1HL091172-01]
- The NIH Genes, Environment and Health Initiative (GEI) at Johns Hopkins University Center for Inherited Disease Research [U01HG004438, NIH HHSN268200782096C]
- NIH grants [P50 CA70907, R01CA121197, R01CA127219, U19 CA148127, R01 CA55769, K07CA160753]
- CPRIT grant [RP100443]
- NIH (National Cancer Institute) [CA092824, CA090578, CA074386]
- National Institutes of Health [R01-DA017932]
- Institut National du Cancer, France
- European Community (Integrated Project DNA repair) [LSHG-CT-2005-512113]
- European Regional Development Fund
- State Budget of the Czech Republic [RECAMO, CZ.1.05/2.1.00/03.0101]
- Westat, Inc. [NO1-CN-25476]
- federal contract from the NIH [HHSN268200782096C]
- The NIH Genes, Environment and Health Initiative (GEI) at GENEVA Coordination Center [U01 HG004446]
- [GENADDICT: LSHMCT-2004-005166]
The T-cell protein tyrosine phosphatase (TCPTP) pathway consists of signaling events mediated by TCPTP. Mutations and genetic variants of some genes in the TCPTP pathway are associated with lung cancer risk and survival. In the present study, we first investigated associations of 5,162 single nucleotide polymorphisms (SNPs) in 43 genes of this TCPTP pathway with lung cancer risk by using summary data of six published genome-wide association studies (GWAS) of 12,160 cases and 16,838 controls. We identified 11 independent SNPs in eight genes after correction for multiple comparisons by a false discovery rate <0.20. Then, we performed in silico functional analyses for these 11 SNPs by eQTL analysis, two of which, PTPN2 SNPs rs2847297 and rs2847282, were chosen as tagSNPs. We further included two additional GWAS datasets of Harvard University (984 cases and 970 controls) and deCODE (1,319 cases and 26,380 controls), and the overall effects of these two SNPs among all eight GWAS studies remained significant (OR = 0.95, 95% CI = 0.92-0.98, and P = 0.004 for rs2847297; OR = 0.95, 95% CI = 0.92-0.99, and P = 0.009 for rs2847282). In conclusion, the PTPN2 rs2847297 and rs2847282 may be potential susceptible loci for lung cancer risk.
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