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Irina Vetter et al.
PHARMACOLOGY & THERAPEUTICS (2017)
The hitchhiker's guide to the voltage-gated sodium channel galaxy
Christopher A. Ahern et al.
JOURNAL OF GENERAL PHYSIOLOGY (2016)
Engineering Highly Potent and Selective Microproteins against Nav1.7 Sodium Channel for Treatment of Pain
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Single Residue Substitutions That Confer Voltage-Gated Sodium Ion Channel Subtype Selectivity in the NaV1.7 Inhibitory Peptide GpTx-1
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JOURNAL OF MEDICINAL CHEMISTRY (2016)
Molecular determinant for the tarantula toxin Jingzhaotoxin-I slowing the fast inactivation of voltage-gated sodium channels
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Molecular basis of the interaction between gating modifier spider toxins and the voltage sensor of voltage-gated ion channels
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Binary architecture of the Nav1.2-β2 signaling complex
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Seven novel modulators of the analgesic target NaV1.7 uncovered using a high-throughput venom-based discovery approach
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BRITISH JOURNAL OF PHARMACOLOGY (2015)
Engineering Potent and Selective Analogues of GpTx-1, a Tarantula Venom Peptide Antagonist of the Na(V)1.7 Sodium Channel
Justin K. Murray et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
Mapping the interaction site for the tarantula toxin hainantoxin-IV (β-TRTX-Hn2a) in the voltage sensor module of domain II of voltage-gated sodium channels
Tianfu Cai et al.
PEPTIDES (2015)
Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist
Shivani Ahuja et al.
SCIENCE (2015)
Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula
Chun Yuen Chow et al.
TOXINS (2015)
Rational Engineering Defines a Molecular Switch That Is Essential for Activity of Spider-Venom Peptides against the Analgesics Target NaV1.7
Julie K. Klint et al.
MOLECULAR PHARMACOLOGY (2015)
Nav1.1 Modulation by a Novel Triazole Compound Attenuates Epileptic Seizures in Rodents
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ACS CHEMICAL BIOLOGY (2014)
Isolation, synthesis and characterization of ω-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type Cav channels
Julie K. Klint et al.
BIOCHEMICAL PHARMACOLOGY (2014)
The tarantula toxin jingzhaotoxin-XI (κ-theraphotoxin-Cj1a) regulates the activation and inactivation of the voltage-gated sodium channel Nav1.5
Cheng Tang et al.
TOXICON (2014)
Structure and Function of Hainantoxin-III, a Selective Antagonist of Neuronal Tetrodotoxin-sensitive Voltage-gated Sodium Channels Isolated from the Chinese Bird Spider Ornithoctonus hainana
Zhonghua Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Analysis of the Structural and Molecular Basis of Voltage-sensitive Sodium Channel Inhibition by the Spider Toxin Huwentoxin-IV (μ-TRTX-Hh2a)
Natali A. Minassian et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Domain IV voltage-sensor movement is both sufficient and rate limiting for fast inactivation in sodium channels
Deborah L. Capes et al.
JOURNAL OF GENERAL PHYSIOLOGY (2013)
The NaV1.7 sodium channel: from molecule to man
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NATURE REVIEWS NEUROSCIENCE (2013)
Production of Recombinant Disulfide-Rich Venom Peptides for Structural and Functional Analysis via Expression in the Periplasm of E. coli
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PLOS ONE (2013)
Potency optimization of Huwentoxin-IV on hNav1.7: A neurotoxin TTX-S sodium-channel antagonist from the venom of the Chinese bird-eating spider Selenocosmia huwena
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PEPTIDES (2013)
Crystallographic insights into sodium-channel modulation by the β4 subunit
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Characterisation of Nav types endogenously expressed in human SH-SY5Y neuroblastoma cells
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BIOCHEMICAL PHARMACOLOGY (2012)
Opioid-related (ORL1) receptors are enriched in a subpopulation of sensory neurons and prolonged activation produces no functional loss of surface N-type calcium channels
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JOURNAL OF PHYSIOLOGY-LONDON (2012)
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AMINO ACIDS (2011)
Common Molecular Determinants of Tarantula Huwentoxin-IV Inhibition of Na+ Channel Voltage Sensors in Domains II and IV
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JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Are voltage-gated sodium channels on the dorsal root ganglion involved in the development of neuropathic pain?
Wei Wang et al.
MOLECULAR PAIN (2011)
Differential state-dependent modification of rat Nav1.6 sodium channels expressed in human embryonic kidney (HEK293) cells by the pyrethroid insecticides tefluthrin and deltamethrin
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TOXICOLOGY AND APPLIED PHARMACOLOGY (2011)
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BEHAVIOURAL BRAIN RESEARCH (2010)
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JOURNAL OF MAGNETIC RESONANCE (2010)
The Tarantula Toxins ProTx-II and Huwentoxin-IV Differentially Interact with Human Nav1.7 Voltage Sensors to Inhibit Channel Activation and Inactivation
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MOLECULAR PHARMACOLOGY (2010)
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TRENDS IN PHARMACOLOGICAL SCIENCES (2010)
Spider-Venom Peptides as Therapeutics
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TOXINS (2010)
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JOURNAL OF BIOMOLECULAR NMR (2009)
Jingzhaotoxin-II, a novel tarantula toxin preferentially targets rat cardiac sodium channel
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BIOCHEMICAL PHARMACOLOGY (2008)
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NATURE (2008)
JZTX-IV, a unique acidic sodium channel toxin isolated from the spider Chilobrachys jingzhao
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TOXICON (2008)
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TOXICON (2008)
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NATURE METHODS (2007)
An SCN9A channelopathy causes congenital inability to experience pain
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NATURE (2006)
The voltage-gated sodium channel Nav1.9 is an effector of peripheral inflammatory pain hypersensitivity
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JOURNAL OF NEUROSCIENCE (2006)
SCN9A mutations in paroxysmal extreme pain disorder:: Allelic variants underlie distinct channel defects and phenotypes
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NEURON (2006)
Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes
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MOLECULAR PHARMACOLOGY (2006)
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BIOINFORMATICS (2006)
Changes in electrophysiological properties and sodium channel Nav1.3 expression in thalamic neurons after spinal cord injury
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BRAIN (2005)
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JOURNAL OF MEDICAL GENETICS (2004)
Pharmacologically active spider peptide toxins
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CELLULAR AND MOLECULAR LIFE SCIENCES (2003)
Purification and characterization of Hainantoxin-V, a tetrodotoxin-sensitive sodium channel inhibitor from the venom of the spider Selenocosmia hainana
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TOXICON (2003)
Two tarantula peptides inhibit activation of multiple sodium channels
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BIOCHEMISTRY (2002)
Function and solution structure of huwentoxin-IV, a potent neuronal tetrodotoxin (TTX)-sensitive sodium channel antagonist from Chinese bird spider Selenocosmia huwena
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JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Troubleshooting problems with in vitro screening of drugs for QT interval prolongation using HERG K+ channels expressed in mammalian cell lines and Xenopus oocytes
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JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2002)
Novel tarantula toxins for subtypes of voltage-dependent potassium channels in the Kv2 and Kv4 subfamilies
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MOLECULAR PHARMACOLOGY (2002)
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MOLECULAR BRAIN RESEARCH (2001)
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JOURNAL OF GENERAL PHYSIOLOGY (2000)