期刊
SCIENTIFIC REPORTS
卷 7, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/srep44522
关键词
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资金
- Health and Labour Sciences Research Grants program of the Ministry of Health, Labour, and Welfare [21040101]
- MEXT, Medicine, Dentistry and Pharmacy by the Ministry of Education, Culture, Sports and Technology, Japan [22249064, 26253088]
- Organ Technologies, Inc.
- Grants-in-Aid for Scientific Research [16K15791, 22249064, 26253088, 25253098, 15K15707, 15H06423] Funding Source: KAKEN
Whole-organ regeneration has great potential for the replacement of dysfunctional organs through the reconstruction of a fully functional bioengineered organ using three-dimensional cell manipulation in vitro. Recently, many basic studies of whole-tooth replacement using three-dimensional cell manipulation have been conducted in a mouse model. Further evidence of the practical application to human medicine is required to demonstrate tooth restoration by reconstructing bioengineered tooth germ using a postnatal large-animal model. Herein, we demonstrate functional tooth restoration through the autologous transplantation of bioengineered tooth germ in a postnatal canine model. The bioengineered tooth, which was reconstructed using permanent tooth germ cells, erupted into the jawbone after autologous transplantation and achieved physiological function equivalent to that of a natural tooth. This study represents a substantial advancement in whole-organ replacement therapy through the transplantation of bioengineered organ germ as a practical model for future clinical regenerative medicine.
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