期刊
SCIENTIFIC REPORTS
卷 6, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/srep36541
关键词
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资金
- National Natural Science Foundation of China [81641017, 81170148]
- Zhejiang Provincial Natural Science Foundation [LY15H020008]
- China Postdoctoral Science Foundation [2014M561181]
- Hangzhou Science and Technology Projects [20140633B12]
- Tianjin enterprise postdoctoral prioritizing innovation funding project [2014-26]
- Tianjin Binhai Key Platform for Creative Research Program [2012-BH110004]
- Binhai New Area Health Bureau [2011BHKZ001, 2012BWKZ 008, 2014BWKY002]
- Tianjin Health Bureau [2014KZ005]
Pulmonary arterial hypertension associated with congenital heart disease (CHD-PAH) has serious consequence and plasma protein profiles in CHD-PAH are unknown. We aimed to reveal the differential plasma proteins in 272 CHD patients with or without PAH. Various types of CHD-PAH were studied. Differential plasma proteins were first detected by iTRAQ proteomic technology and those with significant clinical relevance were selected for further ELISA validation in new cohort of patients. Among the 190 differential plasma proteins detected by iTRAQ, carbamoyl-phosphate synthetase I (CPSI, related to urea cycle and endogenous nitric oxide production) and complement factor H-related protein 2 (CFHR2, related to complement system and coagulant mechanism) were selected for further ELISA validation in new cohort of 152 patients. Both CPSI and CFHR2 were down-regulated with decreased plasma levels (p < 0.01). Thus, we for the first time in CHD-PAH patients identified a large number of differential plasma proteins. The decreased CPSI expression in CHD-PAH patients may reveal a mechanism related to endogenous nitric oxide and the decrease of CFHR2 protein may demonstrate the deficiency of the immune system and coagulation mechanism. The findings may open a new direction for translational medicine in CHD-PAH with regard to the diagnosis and progress of the disease.
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