期刊
SCIENTIFIC REPORTS
卷 6, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/srep38573
关键词
-
资金
- Natural Science Foundation of China [21102007, 21372023]
- Shenzhen Science and Technology Innovation Committee [SW201110018, SGLH20120928095602764]
- Pfizer-Peking University platform
- Shenzhen Peacock Program [KQTD201103]
- MOST of China [2013CB911501]
- SZSTI Program [KQCX20130627103353535, GGJS20130329180714793]
Inducing alpha-helicity through side-chain cross-linking is a strategy that has been pursued to improve peptide conformational rigidity and bio-availability. Here we describe the preparation of small peptides tethered to chiral sulfoxide-containing macrocyclic rings. Furthermore, a study of structure-activity relationships (SARs) disclosed properties with respect to ring size, sulfur position, oxidation state, and stereochemistry that show a propensity to induce alpha-helicity. Supporting data include circular dichroism spectroscopy (CD), NMR spectroscopy, and a single crystal X-ray structure for one such stabilized peptide. Finally, theoretical studies are presented to elucidate the effect of chiral sulfoxides in inducing backbone alpha-helicity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据