期刊
SCIENTIFIC REPORTS
卷 6, 期 -, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/srep28237
关键词
-
资金
- National Science Foundation [IIP-1430092]
- National Science and Engineering Research Council of Canada (NSERC)
- Directorate For Engineering
- Div Of Industrial Innovation & Partnersh [1430092] Funding Source: National Science Foundation
Vitamin B-12 is necessary for formation of red blood cells, DNA synthesis, neural myelination, brain development, and growth. Vitamin B-12 deficiency is often asymptomatic early in its course; however, once it manifests, particularly with neurological symptoms, reversal by dietary changes or supplementation becomes less effective. Access to easy, low cost, and personalized nutritional diagnostics could enable individuals to better understand their own deficiencies as well as track the effects of dietary changes. In this work, we present the NutriPhone, a mobile platform for the analysis of blood vitamin B-12 levels in 15 minutes. The NutriPhone technology comprises of a smartphone accessory, an app, and a competitive-type lateral flow test strip that quantifies vitamin B-12 levels. To achieve the detection of sub-nmol/L physiological levels of vitamin B-12, our assay incorporates an innovative spacer pad for increasing the duration of the key competitive binding reaction and uses silver amplification of the initial signal. We demonstrate the efficacy of our NutriPhone system by quantifying physiologically relevant levels of vitamin B-12 and performing human trials where it was used to accurately evaluate blood vitamin B-12 status of 12 participants from just a drop (similar to 40 mu l) of finger prick blood.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据