期刊
SCIENTIFIC REPORTS
卷 6, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/srep23986
关键词
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资金
- National ST Major Project [2012ZX09103101-060]
- Natural Science Foundation of Liaoning Province [2013010434-401]
- National Natural Science Foundation of China [81502932]
- Program for Innovative Research Team of the Ministry of Education and Program for Liaoning Innovative Research Team in University
A series of 3-(3'-hydroxy-4'-methoxyphenyl) selenyl-5,6,7-trimethoxy-1H-indoles and 3-(3'-hydroxy-4'- methoxyphenyl) thio-5,6,7-trimethoxy-1H-indoles were obtained as a new class of combretastatin A-4 (CA-4) analogues via a convenient ultrasound (US)-assisted two-step process involving 3-selenenylation/sulfenylation followed by O-deallylation. With the assistance of US irradiation, both the reaction rates and yields of selenenylation, sulfenylation and O-deallylation could be significantly improved. A comparison of the reaction rates of O-deallylation and ester reduction demonstrated that O-deallylation was more sensitive to US irradiation. Finally, these products were evaluated for their antiproliferative activities, and most of them showed moderate to potent activities against three human cancer cell lines in vitro.
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