期刊
SCIENTIFIC REPORTS
卷 6, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/srep28098
关键词
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资金
- Genetics Core of the Edinburgh Wellcome Trust Clinical Research Facility
- Cancer Research UK [C348/A12076]
- University of Edinburgh
- European Commission IBD-BIOM [305479]
- HighGlycan [278535]
- MIMOmics [305280]
- HTP-GlycoMet [324400]
- IntegraLife [315997]
- MRC [MC_PC_U127527198, MC_U127527198, MR/K018647/1] Funding Source: UKRI
- Cancer Research UK [11378, 12076, 18927] Funding Source: researchfish
- Medical Research Council [MR/K018647/1, MC_PC_U127527198, 1137806, MC_U127527198] Funding Source: researchfish
In this study we demonstrate the potential value of Immunoglobulin G (IgG) glycosylation as a novel prognostic biomarker of colorectal cancer (CRC). We analysed plasma IgG glycans in 1229 CRC patients and correlated with survival outcomes. We assessed the predictive value of clinical algorithms and compared this to algorithms that also included glycan predictors. Decreased galactosylation, decreased sialylation (of fucosylated IgG glycan structures) and increased bisecting GlcNAc in IgG glycan structures were strongly associated with all-cause (q < 0.01) and CRC mortality (q = 0.04 for galactosylation and sialylation). Clinical algorithms showed good prediction of all-cause and CRC mortality (Harrell's C: 0.73, 0.77; AUC: 0.75, 0.79, IDI: 0.02, 0.04 respectively). The inclusion of IgG glycan data did not lead to any statistically significant improvements overall, but it improved the prediction over clinical models for stage 4 patients with the shortest follow-up time until death, with the median gain in the test AUC of 0.08. These glycan differences are consistent with significantly increased IgG pro-inflammatory activity being associated with poorer CRC prognosis, especially in late stage CRC. In the absence of validated biomarkers to improve upon prognostic information from existing clinicopathological factors, the potential of these novel IgG glycan biomarkers merits further investigation.
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