期刊
SCIENTIFIC REPORTS
卷 6, 期 -, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/srep28433
关键词
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资金
- Iran National Science Foundation
- Tarbiat Modares University, Tehran, Iran
Gene modified or cytokine activated mesenchymal stem cells (MSCs) have been used as a treatment in various types of cancer. Moreover, irradiation is usually applied as either a standard primary or adjuvant therapy. Here, we showed that the expression of TNF related apoptosis-inducing ligand (TRAIL) and Dickouf-3 (Dkk-3), the promising anticancer proteins, increased in murine adipose-derived mesenchymal stromal cells (AD-MSCs) following activation with TNF-alpha, resulting in the induction of apoptosis in cancer cells. Also, anticancer effects of TNF-alpha activated AD-MSCs were intensified with irradiation. In vivo results showed that TNF-alpha preactivated AD-MSCs combined with irradiation decreased tumor size and increased survival rate in tumor bearing mice. On the other hands, both TNF-alpha preactivated AD-MSCs with or without irradiation prevented metastasis in ling and liver, and increased apoptosis in tumor mass. Finally, flowcytometry assay demonstrated that naive AD-MSCs combined with irradiation but not TNF-alpha activated MSCs with irradiation increased Treg population in lymph node and spleen. Altogether, obtained results suggest that TNF-alpha activated MSCs combined with irradiation therapy can serve as new strategy in breast cancer therapy.
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