期刊
SCIENTIFIC REPORTS
卷 6, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/srep20664
关键词
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资金
- Leverhulme Trust [RPG-2012-558]
- Biotechnology and Biological Sciences Research Council (BBSRC) [BB/G016658/1]
- Biotechnology and Biological Sciences Research Council [BB/M018040/1, BB/G016658/1] Funding Source: researchfish
- Medical Research Council [MR/M010341/1] Funding Source: researchfish
- BBSRC [BB/M018040/1, BB/G016658/1] Funding Source: UKRI
- MRC [MR/M010341/1] Funding Source: UKRI
Synthetic biology provides an opportunity for the construction and exploration of alternative solutions to biological problems - solutions different from those chosen by natural life. To this end, synthetic biologists have built new sensory systems, cellular memories, and alternative genetic codes. There is a growing interest in applying synthetic approaches to multicellular systems, especially in relation to multicellular self-organization. Here we describe a synthetic biological system that confers large-scale de novo patterning activity on 2-D and 3-D populations of mammalian cells. Instead of using the reaction-diffusion mechanisms common in real embryos, our system uses cadherin-mediated phase separation, inspired by the known phenomenon of cadherin-based sorting. An engineered self-organizing, large-scale patterning system requiring no prior spatial cue may be a significant step towards the construction of self-assembling synthetic tissues.
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