期刊
SCIENTIFIC REPORTS
卷 6, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/srep19646
关键词
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资金
- Public Welfare & Safety research program through the National Research Foundation of Korea - Ministry of Science, ICT and Future Planning (MSIP) [NRF-2012M3A2A1051682, NRF-2012M3A2A1051686]
- Global Frontier Project through the Center for BioNano Health-Guard - MSIP [H-GUARD_2014M3A6B2060489]
- KRIBB initiative Research Program
- Global Ph.D. Fellowship [NRF-2011-0030947]
Uranium is an essential raw material in nuclear energy generation; however, its use raises concerns about the possibility of severe damage to human health and the natural environment. In this work, we report an ultrasensitive uranyl ion (UO22+) detection method in natural water that uses a plasmonic nanowire interstice (PNI) sensor combined with a DNAzyme-cleaved reaction. UO22+ induces the cleavage of DNAzymes into enzyme strands and released strands, which include Raman-active molecules. A PNI sensor can capture the released strands, providing strong surface-enhanced Raman scattering signal. The combination of a PNI sensor and a DNAzyme-cleaved reaction significantly improves the UO22+ detection performance, resulting in a detection limit of 1 pM and high selectivity. More importantly, the PNI sensor operates perfectly, even in UO22+-contaminated natural water samples. This suggests the potential usefulness of a PNI sensor in practical UO22+-sensing applications. We anticipate that diverse toxic metal ions can be detected by applying various ion-specific DNA-based ligands to PNI sensors.
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