期刊
SCIENTIFIC REPORTS
卷 6, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/srep21711
关键词
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资金
- Natural Science Foundation of Jiangsu Province [BK20130544, BK20140017, BK20130558, BK20150055]
- National Key Basic Research Program of China [2015CB921600, 2013CBA01603]
- National Natural Science Foundation of China [21307055, 11374142, 61574076]
- Specialized Research Fund for the Doctoral Program of Higher Education [20130091120040]
- Fundamental Research Funds for the Central Universities
- Collaborative Innovation Center of Advanced Microstructures
Lead is a cumulative toxicant, which can induce severe health issues, especially in children's case due to their immature nervous system. While realizing large-scale monitoring of children blood lead remains challenging by utilizing traditional methods, it is highly desirable to search for alternative techniques or novel sensing materials. Here we report a label-free and portable aptasensor based on graphene field effect transistor (FET) for effective children blood lead detection. With standard solutions of different Pb2+ concentrations, we obtained a dose-response curve and a detection limitation below 37.5 ng/L, which is three orders lower than the safe blood lead level (100 mu g/L). The devices also showed excellent selectivity over other metal cations such as, Na+, K+, Mg2+, and Ca2+, suggesting the capability of working in a complex sample matrix. We further successfully demonstrated the detection of Pb2+ ions in real blood samples from children by using our aptasensors, and explored their potential applications for quantification. Our results underscore such graphene FET aptasensors for future applications on fast detection of heavy metal ions for health monitoring and disease diagnostics.
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