期刊
SCIENTIFIC REPORTS
卷 5, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/srep14167
关键词
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资金
- NIH Director's New Innovator Award [DP2-HD075698]
- Louis V. Gerstner Jr. Young Investigator's Fund
- Frank A. Howard Scholars Program
- Alan and Sandra Gerry Metastasis Research Initiative
- Center for Molecular Imaging and Nanotechnology at Memorial Sloan-Kettering Cancer Center [P30 CA008748]
- American Cancer Society-Roaring Fork Valley Research Fellowship
The intrinsic near-infrared photoluminescence (fluorescence) of single-walled carbon nanotubes exhibits unique photostability, narrow bandwidth, penetration through biological media, environmental sensitivity, and both chromatic variety and range. Biomedical applications exploiting this large family of fluorophores will require the spectral and spatial resolution of individual (n,m) nanotube species' fluorescence and its modulation within live cells and tissues, which is not possible with current microscopy methods. We present a wide-field hyperspectral approach to spatially delineate and spectroscopically measure single nanotube fluorescence in living systems. This approach resolved up to 17 distinct (n, m) species (chiralities) with single nanotube spatial resolution in live mammalian cells, murine tissues ex vivo, and zebrafish endothelium in vivo. We anticipate that this approach will facilitate multiplexed nanotube imaging in biomedical applications while enabling deep-tissue optical penetration, and single-molecule resolution in vivo.
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