期刊
ALLERGOLOGY INTERNATIONAL
卷 64, 期 1, 页码 17-26出版社
JAPANESE SOCIETY ALLERGOLOGY
DOI: 10.1016/j.alit.2014.09.001
关键词
Allergic diseases; CysLTs; Leukotrienes; Lipid mediators; LTB4
资金
- Grants-in-Aid for Scientific Research [22116002, 22116001, 15H05897] Funding Source: KAKEN
Leukotrienes (LTs), both LTB4 and the cysteinyl LTs (CysLTs) LTC4, LTD4 and LTE4, are implicated in a wide variety of inflammatory disorders. These lipid mediators are generated from arachidonic acid via multistep enzymatic reactions through which arachidonic acid is liberated from membrane phospholipids through the action of phospholipase A(2). LTB4 and CysLTs exert their biological effects by binding to cognate receptors, which belong to the G protein-coupled receptor superfamily. LTB4 is widely considered to be a potent chemoattractant for most subsets of leukocytes, whereas CysLTs are potent bronchoconstrictors that have effects on airway remodeling. LTs play a central role in the pathogenesis of asthma and many other inflammatory diseases. This review will provide an update on the synthesis, biological function, and relevance of LTs to the pathobiology of allergic diseases, and examine the current and future therapeutic prospects of LT modifiers. Copyright (C) 2014, Japanese Society of Allergology. Production and hosting by Elsevier B.V. All rights reserved.
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