期刊
SCIENTIFIC REPORTS
卷 4, 期 -, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/srep05147
关键词
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资金
- National Natural Science Foundation of China [30870572, 61303161, 61103167]
- National High-tech R&D Program (863 Program) - Ministry of Science and Technology of China [2012AA02A707, 2014AA021502]
- NVIDIA
- Key Laboratory for Rare and Uncommon Diseases of Shandong Province, P.R. China
Although Traditional Chinese Medicine (TCM) preparations have long history with successful applications, the scientific and systematic quality assessment of TCM preparations mainly focuses on chemical constituents and is far from comprehensive. There are currently only few primitive studies on assessment of biological ingredients in TCM preparations. Here, we have proposed a method, M-TCM, for biological assessment of the quality of TCM preparations based on high-throughput sequencing and metagenomic analysis. We have tested this method on Liuwei Dihuang Wan (LDW), a TCM whose ingredients have been well-defined. Our results have shown that firstly, this method could determine the biological ingredients of LDW preparations. Secondly, the quality and stability of LDW varies significantly among different manufacturers. Thirdly, the overall quality of LDW samples is significantly affected by their biological contaminations. This novel strategy has the potential to achieve comprehensive ingredient profiling of TCM preparations.
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