期刊
SCIENTIFIC REPORTS
卷 4, 期 -, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/srep05313
关键词
-
资金
- Outstanding Young Scientists of Organization Department, National HighTech Research and Development Program of China [2014AA020609]
- Specialized Research Fund for the Doctoral Program of Higher Education [20130142110017]
- Xiaoping Miao and the National Natural Science Foundation of China [NSFC-81001275, 81171878, 81222038]
Multiple studies have hypothesized parity is associated with pancreatic cancer risk but obtained conflicting results. We conducted a meta-analysis (including a dose-response approach) of current available epidemiologic studies to investigate the association between parity and risk of pancreatic cancer. Ten cohort studies and ten case-control studies including 8205 cases were eligible for inclusion. The combined RR (relative risk) of pancreatic cancer for the parous vs. nulliparous was 0.91 (95% CI, confidence interval 5 0.85-0.97, I-2 = 39.0%, P-h = 0.01). We observed an inverse association between giving birth to two children pancreatic cancer risk with RR of 0.86 (95% CI = 0.80-0.93, I-2 = 8.7%, P-h = 0.36). And no evidence supported there was non-linear (P = 0.33) or linear relationship (P=0.14) between number of parity and risk of pancreatic cancer. Findings from this meta-analysis indicate that giving birth to two children has the lowest pancreatic cancer risk, mechanism of this protective effect needs further investigation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据